Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance
Abstract Background Liver cirrhosis and chronic infection with hepatitis B virus are major risk factors for hepatocellular carcinoma (HCC). Guidelines recommend ultrasound (US) surveillance for population at risk of HCC. The US Liver Imaging Reporting and Data System (LI-RADS) aims at standardizatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-08-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01083-0 |
| _version_ | 1797453451131617280 |
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| author | Ahmed Haitham Abduljabbar Mohammad A. Wazzan |
| author_facet | Ahmed Haitham Abduljabbar Mohammad A. Wazzan |
| author_sort | Ahmed Haitham Abduljabbar |
| collection | DOAJ |
| description | Abstract Background Liver cirrhosis and chronic infection with hepatitis B virus are major risk factors for hepatocellular carcinoma (HCC). Guidelines recommend ultrasound (US) surveillance for population at risk of HCC. The US Liver Imaging Reporting and Data System (LI-RADS) aims at standardization of interpretation, reporting, and management recommendations for US surveillance examinations. The aim of this study is to assess the diagnostic accuracy of US LI-RADS in early HCC detection in patients at risk. Results This retrospective study included patients with surveillance US between January 2018 and January 2020 who had a contrast-enhanced CT or MRI of the liver within 1 month from the date of US examination. Visualization scores and US categories were assigned according to the US LI-RADS lexicon. A total of 264 participants were eligible for the study. HCC was diagnosed in 33 participants. The US-3 category had a 39.4% sensitivity and 93.5% specificity for HCC detection. The US-2 category had a 45.4% sensitivity and 87% specificity for HCC detection. The visualization score C showed the highest number of HCC (19/33) and had the highest false-negative rate (76%, 13 of 17). Conclusions Both US-2 and US-3 categories showed high specificity and low sensitivity for HCC detection in the setting of surveillance of patients at high risk. Visualization score C had the highest risk for HCC and the highest rate of false-negative results. Intense surveillance by contrast-enhanced CT or MRI might be beneficial for patients with limited visualization scores B and C. |
| first_indexed | 2024-03-09T15:23:00Z |
| format | Article |
| id | doaj.art-017a5fbbe80a4005929a06da82b7736d |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-03-09T15:23:00Z |
| publishDate | 2023-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-017a5fbbe80a4005929a06da82b7736d2023-11-26T12:41:06ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-08-015411510.1186/s43055-023-01083-0Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillanceAhmed Haitham Abduljabbar0Mohammad A. Wazzan1Department of Radiology, Faculty of Medicine, King Abdulaziz UniversityDepartment of Radiology, Faculty of Medicine, King Abdulaziz UniversityAbstract Background Liver cirrhosis and chronic infection with hepatitis B virus are major risk factors for hepatocellular carcinoma (HCC). Guidelines recommend ultrasound (US) surveillance for population at risk of HCC. The US Liver Imaging Reporting and Data System (LI-RADS) aims at standardization of interpretation, reporting, and management recommendations for US surveillance examinations. The aim of this study is to assess the diagnostic accuracy of US LI-RADS in early HCC detection in patients at risk. Results This retrospective study included patients with surveillance US between January 2018 and January 2020 who had a contrast-enhanced CT or MRI of the liver within 1 month from the date of US examination. Visualization scores and US categories were assigned according to the US LI-RADS lexicon. A total of 264 participants were eligible for the study. HCC was diagnosed in 33 participants. The US-3 category had a 39.4% sensitivity and 93.5% specificity for HCC detection. The US-2 category had a 45.4% sensitivity and 87% specificity for HCC detection. The visualization score C showed the highest number of HCC (19/33) and had the highest false-negative rate (76%, 13 of 17). Conclusions Both US-2 and US-3 categories showed high specificity and low sensitivity for HCC detection in the setting of surveillance of patients at high risk. Visualization score C had the highest risk for HCC and the highest rate of false-negative results. Intense surveillance by contrast-enhanced CT or MRI might be beneficial for patients with limited visualization scores B and C.https://doi.org/10.1186/s43055-023-01083-0Hepatocellular carcinomaSurveillanceLiver cirrhosisUltrasoundUltrasound LI-RADS |
| spellingShingle | Ahmed Haitham Abduljabbar Mohammad A. Wazzan Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance The Egyptian Journal of Radiology and Nuclear Medicine Hepatocellular carcinoma Surveillance Liver cirrhosis Ultrasound Ultrasound LI-RADS |
| title | Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance |
| title_full | Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance |
| title_fullStr | Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance |
| title_full_unstemmed | Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance |
| title_short | Diagnostic performance of US LI-RADS in hepatocellular carcinoma surveillance |
| title_sort | diagnostic performance of us li rads in hepatocellular carcinoma surveillance |
| topic | Hepatocellular carcinoma Surveillance Liver cirrhosis Ultrasound Ultrasound LI-RADS |
| url | https://doi.org/10.1186/s43055-023-01083-0 |
| work_keys_str_mv | AT ahmedhaithamabduljabbar diagnosticperformanceofusliradsinhepatocellularcarcinomasurveillance AT mohammadawazzan diagnosticperformanceofusliradsinhepatocellularcarcinomasurveillance |