Coronary Vasculature in Cardiac Development and Regeneration
Functional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/5/4/59 |
| _version_ | 1818155040051822592 |
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| author | Subir Kapuria Tyler Yoshida Ching-Ling Lien |
| author_facet | Subir Kapuria Tyler Yoshida Ching-Ling Lien |
| author_sort | Subir Kapuria |
| collection | DOAJ |
| description | Functional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration is still limited. It is demonstrated that early revascularization is required for efficient heart regeneration. In this comprehensive review, we first describe the coronary vessel formation from an evolutionary perspective. We further discuss the cell origins of coronary endothelial cells and perivascular cells and summarize the critical signaling pathways regulating coronary vessel development. Lastly, we focus on the current knowledge about the molecular mechanisms regulating heart regeneration in zebrafish, a genetically tractable vertebrate model with a regenerative adult heart and well-developed coronary system. |
| first_indexed | 2024-12-11T14:36:04Z |
| format | Article |
| id | doaj.art-017a67a93a514e3a9391f56ebf9511bf |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-12-11T14:36:04Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-017a67a93a514e3a9391f56ebf9511bf2022-12-22T01:02:10ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252018-12-01545910.3390/jcdd5040059jcdd5040059Coronary Vasculature in Cardiac Development and RegenerationSubir Kapuria0Tyler Yoshida1Ching-Ling Lien2The Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USAThe Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USAThe Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USAFunctional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration is still limited. It is demonstrated that early revascularization is required for efficient heart regeneration. In this comprehensive review, we first describe the coronary vessel formation from an evolutionary perspective. We further discuss the cell origins of coronary endothelial cells and perivascular cells and summarize the critical signaling pathways regulating coronary vessel development. Lastly, we focus on the current knowledge about the molecular mechanisms regulating heart regeneration in zebrafish, a genetically tractable vertebrate model with a regenerative adult heart and well-developed coronary system.https://www.mdpi.com/2308-3425/5/4/59heart regenerationcoronary vesselsendothelial cellsperivascular cells |
| spellingShingle | Subir Kapuria Tyler Yoshida Ching-Ling Lien Coronary Vasculature in Cardiac Development and Regeneration Journal of Cardiovascular Development and Disease heart regeneration coronary vessels endothelial cells perivascular cells |
| title | Coronary Vasculature in Cardiac Development and Regeneration |
| title_full | Coronary Vasculature in Cardiac Development and Regeneration |
| title_fullStr | Coronary Vasculature in Cardiac Development and Regeneration |
| title_full_unstemmed | Coronary Vasculature in Cardiac Development and Regeneration |
| title_short | Coronary Vasculature in Cardiac Development and Regeneration |
| title_sort | coronary vasculature in cardiac development and regeneration |
| topic | heart regeneration coronary vessels endothelial cells perivascular cells |
| url | https://www.mdpi.com/2308-3425/5/4/59 |
| work_keys_str_mv | AT subirkapuria coronaryvasculatureincardiacdevelopmentandregeneration AT tyleryoshida coronaryvasculatureincardiacdevelopmentandregeneration AT chinglinglien coronaryvasculatureincardiacdevelopmentandregeneration |