Synthesis, Stability Studies, and Antifungal Evaluation of Substituted α- and β-2,3-Dihydrofuranaphthoquinones against Sporothrix brasiliensis and Sporothrix schenckii

Synthesis, Stability Studies, and Antifungal Evaluation of Substituted α- and β-2,3-Dihydrofuranaphthoquinones against Sporothrix brasiliensis and Sporothrix schenckii

Sporotrichosis is a neglected fungal infection caused by Sporothrix spp., which have a worldwide distribution. The standard antifungal itraconazole has been recommended as a first-line therapy. However, failure cases in human and feline treatment have been reported in recent years. This study aimed...

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Bibliographic Details
Main Authors: Patricia Garcia Ferreira, Luana Pereira Borba-Santos, Leticia Lorena Noronha, Caroline Deckman Nicoletti, Marcella de Sá Haddad Queiroz, Fernando de Carvalho da Silva, Sônia Rozental, Débora Omena Futuro, Vitor Francisco Ferreira
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
furanophthoquinones
antifungal
Sporothrix brasiliensis
Sporothrix schenckii
stability study
Online Access:http://www.mdpi.com/1420-3049/24/5/930

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