Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study
<p>Abstract</p> <p>Background</p> <p>Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the <it>ADIPOQ </it>gene on the chromosomal locus 3q27. Variations in...
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| Format: | Article |
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BMC
2011-01-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/12/5 |
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| author | Venojärvi Mika Eriksson Johan G Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti |
| author_facet | Venojärvi Mika Eriksson Johan G Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti |
| author_sort | Venojärvi Mika |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the <it>ADIPOQ </it>gene on the chromosomal locus 3q27. Variations in <it>ADIPOQ </it>are associated with obesity, type 2 diabetes (T2DM) and related phenotypes in several populations. Our aim was to study the association of the <it>ADIPOQ </it>variations with body weight, serum adiponectin concentrations and conversion to T2DM in overweight subjects with impaired glucose tolerance. Moreover, we investigated whether <it>ADIPOQ </it>gene variants modify the effect of lifestyle changes on these traits.</p> <p>Methods</p> <p>Participants in the Finnish Diabetes Prevention Study were randomly assigned to a lifestyle intervention group or a control group. Those whose DNA was available (n = 507) were genotyped for ten <it>ADIPOQ </it>single nucleotide polymorphisms (SNPs). Associations between SNPs and baseline body weight and serum adiponectin concentrations were analysed using the univariate analysis of variance. The 4-year longitudinal weight data were analysed using linear mixed models analysis and the change in serum adiponectin from baseline to year four was analysed using Kruskal-Wallis test. In addition, the association of SNPs with the risk of developing T2DM during the follow-up of 0-11 (mean 6.34) years was analysed by Cox regression analysis.</p> <p>Results</p> <p>rs266729, rs16861205, rs1501299, rs3821799 and rs6773957 associated significantly (p < 0.05) with body weight at baseline and in the longitudinal analyses. The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM. The differences in baseline serum adiponectin concentrations were seen according to rs16861210, rs17366568, rs2241766, rs6773957 and rs2082940 and differences in the change of serum adiponectin levels from baseline to the four year examination were seen according to rs16861205, especially in subjects who were able to lose weight during the first year of intervention.</p> <p>Conclusions</p> <p>These results from the Finnish Diabetes Prevention Study support the concept that genetic variation in <it>ADIPOQ </it>locus contributes to variation in body size and serum adiponectin concentrations and may also modify the risk of developing T2DM.</p> <p>Trial registration number</p> <p>ClinicalTrials.gov NCT00518167</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
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| spelling | doaj.art-017eada419a54d99b046d32d38dde8c92022-12-21T23:25:02ZengBMCBMC Medical Genetics1471-23502011-01-01121510.1186/1471-2350-12-5Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention StudyVenojärvi MikaEriksson Johan GKolehmainen MarjukkaLindström JaanaPulkkinen LeenaSiitonen NiinaIlanne-Parikka PirjoKeinänen-Kiukaanniemi SirkkaTuomilehto JaakkoUusitupa Matti<p>Abstract</p> <p>Background</p> <p>Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the <it>ADIPOQ </it>gene on the chromosomal locus 3q27. Variations in <it>ADIPOQ </it>are associated with obesity, type 2 diabetes (T2DM) and related phenotypes in several populations. Our aim was to study the association of the <it>ADIPOQ </it>variations with body weight, serum adiponectin concentrations and conversion to T2DM in overweight subjects with impaired glucose tolerance. Moreover, we investigated whether <it>ADIPOQ </it>gene variants modify the effect of lifestyle changes on these traits.</p> <p>Methods</p> <p>Participants in the Finnish Diabetes Prevention Study were randomly assigned to a lifestyle intervention group or a control group. Those whose DNA was available (n = 507) were genotyped for ten <it>ADIPOQ </it>single nucleotide polymorphisms (SNPs). Associations between SNPs and baseline body weight and serum adiponectin concentrations were analysed using the univariate analysis of variance. The 4-year longitudinal weight data were analysed using linear mixed models analysis and the change in serum adiponectin from baseline to year four was analysed using Kruskal-Wallis test. In addition, the association of SNPs with the risk of developing T2DM during the follow-up of 0-11 (mean 6.34) years was analysed by Cox regression analysis.</p> <p>Results</p> <p>rs266729, rs16861205, rs1501299, rs3821799 and rs6773957 associated significantly (p < 0.05) with body weight at baseline and in the longitudinal analyses. The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM. The differences in baseline serum adiponectin concentrations were seen according to rs16861210, rs17366568, rs2241766, rs6773957 and rs2082940 and differences in the change of serum adiponectin levels from baseline to the four year examination were seen according to rs16861205, especially in subjects who were able to lose weight during the first year of intervention.</p> <p>Conclusions</p> <p>These results from the Finnish Diabetes Prevention Study support the concept that genetic variation in <it>ADIPOQ </it>locus contributes to variation in body size and serum adiponectin concentrations and may also modify the risk of developing T2DM.</p> <p>Trial registration number</p> <p>ClinicalTrials.gov NCT00518167</p>http://www.biomedcentral.com/1471-2350/12/5 |
| spellingShingle | Venojärvi Mika Eriksson Johan G Kolehmainen Marjukka Lindström Jaana Pulkkinen Leena Siitonen Niina Ilanne-Parikka Pirjo Keinänen-Kiukaanniemi Sirkka Tuomilehto Jaakko Uusitupa Matti Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study BMC Medical Genetics |
| title | Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study |
| title_full | Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study |
| title_fullStr | Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study |
| title_full_unstemmed | Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study |
| title_short | Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study |
| title_sort | association of adipoq gene variants with body weight type 2 diabetes and serum adiponectin concentrations the finnish diabetes prevention study |
| url | http://www.biomedcentral.com/1471-2350/12/5 |
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