Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran
Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2014-10-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-490&slc_lang=en&sid=1 |
| _version_ | 1811287600978198528 |
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| author | Fatemeh Zanganeh Amir Jalali Hamid Galehdari Ghazaleh Mohammadzadeh Shahriary Mohamed Taha Jalali Javad Mohammadi-Asl |
| author_facet | Fatemeh Zanganeh Amir Jalali Hamid Galehdari Ghazaleh Mohammadzadeh Shahriary Mohamed Taha Jalali Javad Mohammadi-Asl |
| author_sort | Fatemeh Zanganeh |
| collection | DOAJ |
| description | Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure to carcinogens. The purpose of the present study was to assess genotype and allele frequencies of polymorphic CYP2E1*5B in the Iranian population. Material and Methods: This study was performed on 200 healthy individuals (female: 100, male: 100) in medical laboratories of Ahvaz during 2011. The CYP2E1 *5B (rs3813867 G-1293C) assessment was carried out using PCR-RFLP method. The data were analyzed with ĸ2 and hardy-Weinberg Equation statistically methods. Results: The frequency of *1A/*1A (c1/c1), *1A/*5B (c1/c2) and *5B/*5B (c2/c2) genotypes was computed 97, 3 and 0 percent, respectively. The frequency of *1A (c1) and *5B (c2) alleles was computed 98.5 and 1.5 percent, respectively. No statistically significant difference was between two genders (p>0.05). Conclusion: The genotype distribution and allele frequencies of CYP2E1*5B polymorphism were similar to Turkish and some of the European populations. However, there are significant interethnic differences when the Iranian population is compared with the Eastern Asian, American and some of the European populations. The allelic distribution of this polymorphism did not vary with gender. |
| first_indexed | 2024-04-13T03:21:24Z |
| format | Article |
| id | doaj.art-017f0d7289f347d5863f513decf79516 |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-04-13T03:21:24Z |
| publishDate | 2014-10-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-017f0d7289f347d5863f513decf795162022-12-22T03:04:45ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542014-10-01174582592Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of IranFatemeh Zanganeh0Amir Jalali1Hamid Galehdari2Ghazaleh Mohammadzadeh Shahriary3Mohamed Taha Jalali4Javad Mohammadi-Asl5 Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure to carcinogens. The purpose of the present study was to assess genotype and allele frequencies of polymorphic CYP2E1*5B in the Iranian population. Material and Methods: This study was performed on 200 healthy individuals (female: 100, male: 100) in medical laboratories of Ahvaz during 2011. The CYP2E1 *5B (rs3813867 G-1293C) assessment was carried out using PCR-RFLP method. The data were analyzed with ĸ2 and hardy-Weinberg Equation statistically methods. Results: The frequency of *1A/*1A (c1/c1), *1A/*5B (c1/c2) and *5B/*5B (c2/c2) genotypes was computed 97, 3 and 0 percent, respectively. The frequency of *1A (c1) and *5B (c2) alleles was computed 98.5 and 1.5 percent, respectively. No statistically significant difference was between two genders (p>0.05). Conclusion: The genotype distribution and allele frequencies of CYP2E1*5B polymorphism were similar to Turkish and some of the European populations. However, there are significant interethnic differences when the Iranian population is compared with the Eastern Asian, American and some of the European populations. The allelic distribution of this polymorphism did not vary with gender.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-490&slc_lang=en&sid=1polymorphism CYP2E1*5B genotype allele frequencies IRAN |
| spellingShingle | Fatemeh Zanganeh Amir Jalali Hamid Galehdari Ghazaleh Mohammadzadeh Shahriary Mohamed Taha Jalali Javad Mohammadi-Asl Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran Iranian South Medical Journal polymorphism CYP2E1*5B genotype allele frequencies IRAN |
| title | Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran |
| title_full | Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran |
| title_fullStr | Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran |
| title_full_unstemmed | Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran |
| title_short | Genotype and allelic frequencies of CYP2E1*5B polymorphism in the southwest population of Iran |
| title_sort | genotype and allelic frequencies of cyp2e1 5b polymorphism in the southwest population of iran |
| topic | polymorphism CYP2E1*5B genotype allele frequencies IRAN |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-490&slc_lang=en&sid=1 |
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