A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression

A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression

Hepatic stellate cells (HSCs) represent a significant component of hepatocellular carcinoma (HCC) microenvironments which play a critical role in tumor progression and drug resistance. Tumor-on-a-chip technology has provided a powerful in vitro platform to investigate the crosstalk between activated...

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Bibliographic Details
Main Authors: Peiliang Shen, Yuanyuan Jia, Weijia Zhou, Weiwei Zheng, Yueyao Wu, Suchen Qu, Shiyu Du, Siliang Wang, Huilian Shi, Jia Sun, Xin Han
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
HCC-on-a-chip model
Hepatic stellate cells
Tumor microenvironment
Endothelial invasion
Sorafenib resistance
NK cell Exhaustion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001454

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