Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells

Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells

The use of stem cells is part of a strategy for the treatment of a large number of diseases. However, the source of the original stem cells for use is extremely important and determines their therapeutic potential. Mesenchymal stromal cells (MSC) have proven their therapeutic effectiveness when used...

Full description

Bibliographic Details
Main Authors:	Valentina A. Babenko, Denis N. Silachev, Tatyana I. Danilina, Kirill V. Goryunov, Irina B. Pevzner, Ljubava D. Zorova, Vasily A. Popkov, Valery P. Chernikov, Egor Y. Plotnikov, Gennady T. Sukhikh, Dmitry B. Zorov
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Cells
Subjects:	mitochondria aging senescence stem mesenchymal stromal cells proliferation
Online Access:	https://www.mdpi.com/2073-4409/10/6/1273

Similar Items

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery
by: Valentina A. Babenko, et al.
Published: (2018-03-01)

Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons
by: Dmitry B. Zorov, et al.
Published: (2021-08-01)

Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?
by: Ljubava D. Zorova, et al.
Published: (2022-07-01)

Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury
by: Nadezda V. Andrianova, et al.
Published: (2018-10-01)

Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update
by: Dmitry B. Zorov, et al.
Published: (2019-02-01)

Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury
by: Egor Y. Plotnikov, et al.
Published: (2019-06-01)

Is the Mitochondrial Membrane Potential (∆Ψ) Correctly Assessed? Intracellular and Intramitochondrial Modifications of the ∆Ψ Probe, Rhodamine 123
by: Ljubava D. Zorova, et al.
Published: (2022-01-01)

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia
by: Mikhail M. Moisenovich, et al.
Published: (2020-09-01)

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury
by: Denis N. Silachev, et al.
Published: (2018-07-01)

Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats
by: Nadezda V. Andrianova, et al.
Published: (2022-12-01)

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury
by: Denis N. Silachev, et al.
Published: (2015-08-01)

Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1
by: Ljubava D. Zorova, et al.
Published: (2023-03-01)

Mitochondria as a Source and a Target for Uremic Toxins
by: Vasily A. Popkov, et al.
Published: (2019-06-01)

Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats
by: Egor Y. Plotnikov, et al.
Published: (2018-08-01)

Age-Associated Loss in Renal Nestin-Positive Progenitor Cells
by: Marina I. Buyan, et al.
Published: (2022-09-01)

Sex-Specific Effects of Estradiol and Progesterone in Ischemic Kidney Injury
by: Nadezda V. Andrianova, et al.
Published: (2024-03-01)

Development of an In Vitro Model of SARS-CoV-Induced Acute Lung Injury for Studying New Therapeutic Approaches
by: Yulia A. Shevtsova, et al.
Published: (2022-09-01)

Pros and Cons of Use of Mitochondria-Targeted Antioxidants
by: Egor Y. Plotnikov, et al.
Published: (2019-08-01)

Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation
by: Denis N. Silachev, et al.
Published: (2019-03-01)

A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic
by: Kirill Goryunov, et al.
Published: (2024-03-01)

The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk.
by: Denis N Silachev, et al.
Published: (2012-01-01)

Microbiome-Metabolome Signature of Acute Kidney Injury
by: Nadezda V. Andrianova, et al.
Published: (2020-04-01)

Metabolite Biomarkers for Early Ischemic–Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model
by: Yulia Shevtsova, et al.
Published: (2024-02-01)

Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodelling
by: Ying Xie, et al.
Published: (2022-02-01)

Mitochondrial functional changes characterization in young and senescent human adipose derived MSCs
by: Bernd Robert Stab II, et al.
Published: (2016-12-01)

Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells
by: Dalia Ali, et al.
Published: (2024-04-01)

Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells
by: Chiara Giordani, et al.
Published: (2023-05-01)

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
by: Viktor I. Korolchuk, et al.
Published: (2017-07-01)

Fibrosis Development Linked to Alterations in Glucose and Energy Metabolism and Prooxidant–Antioxidant Balance in Experimental Models of Liver Injury
by: Dmitry S. Semenovich, et al.
Published: (2023-08-01)

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues
by: Shanti Gurung, et al.
Published: (2020-12-01)

Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis
by: Nayra Cárdenes, et al.
Published: (2018-09-01)

Mitochondria in the Nuclei of Rat Myocardial Cells
by: Chupalav M. Eldarov, et al.
Published: (2020-03-01)

Estrogen Plays a Crucial Role in Rab9‐Dependent Mitochondrial Autophagy, Delaying Arterial Senescence
by: Yuichi Sasaki, et al.
Published: (2021-04-01)

Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45<sup>low</sup>CD271<sup>+</sup> Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation
by: Payal Ganguly, et al.
Published: (2020-07-01)

IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors
by: Nicola Alessio, et al.
Published: (2024-02-01)

Implication of Cellular Senescence in Osteoarthritis: A Study on Equine Synovial Fluid Mesenchymal Stromal Cells
by: Gabriella Teti, et al.
Published: (2023-02-01)

Genome-Wide Methylation Changes Associated with Replicative Senescence and Differentiation in Endothelial and Bone Marrow Mesenchymal Stromal Cells
by: Angelica Giuliani, et al.
Published: (2023-01-01)

Anti-Inflammatory Effect of Synaptamide in Ischemic Acute Kidney Injury and the Role of G-Protein-Coupled Receptor 110
by: Anna A. Brezgunova, et al.
Published: (2024-01-01)

Application of mesenchymal stem cells for anti-senescence and clinical challenges
by: Yaping Wang, et al.
Published: (2023-09-01)

Unique Features of the Tissue Structure in the Naked Mole Rat (<i>Heterocephalus glaber</i>): Hypertrophy of the Endoplasmic Reticulum and Spatial Mitochondrial Rearrangements in Hepatocytes
by: Valeriya Vays, et al.
Published: (2022-08-01)