Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
Background and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, ven...
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MDPI AG
2014-01-01
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Series: | Medicina |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1010660X1400072X |
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author | Christer H. Svensen Edgaras Stankevičius Jacob Broms Vytautas Markevičius Audrius Andrijauskas |
author_facet | Christer H. Svensen Edgaras Stankevičius Jacob Broms Vytautas Markevičius Audrius Andrijauskas |
author_sort | Christer H. Svensen |
collection | DOAJ |
description | Background and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, venous plasma dilution induced by a fluid challenge is higher than in the capillaries, and that difference is diminished when the fluid challenge is given to more hydrated individuals. Our objective was to test that hypothesis by evaluating the veno-capillary dilution difference during mVLT in subjects with different hydration status.
Materials and methods: In a prospective randomized crossover study, three mini fluid challenges were given to 12 healthy volunteers on two occasions. The subjects were either dehydrated or hydrated before the experiments.
Results: In dehydrated subjects only, capillary plasma dilution was significantly lower than venous (P = 0.015, 0.005 and 0.006) after each mini fluid challenge.
Conclusions: Veno-capillary dilution difference during mVLT depends on the hydration status. The mVLT method could possibly discriminate between the different states of hydration. |
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institution | Directory Open Access Journal |
issn | 1010-660X |
language | English |
last_indexed | 2024-03-12T09:28:51Z |
publishDate | 2014-01-01 |
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series | Medicina |
spelling | doaj.art-0182bcdcd9e74f61ab7e7921729662b72023-09-02T13:56:18ZengMDPI AGMedicina1010-660X2014-01-0150525526210.1016/j.medici.2014.09.007Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteersChrister H. Svensen0Edgaras Stankevičius1Jacob Broms2Vytautas Markevičius3Audrius Andrijauskas4Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, SwedenInstitute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaSection of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, SwedenDepartment of Electronics Engineering, Kaunas University of Technology, Kaunas, LithuaniaClinic of Anaesthesiology and Intensive Care, Faculty of Medicine, Vilnius University, Vilnius, LithuaniaBackground and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, venous plasma dilution induced by a fluid challenge is higher than in the capillaries, and that difference is diminished when the fluid challenge is given to more hydrated individuals. Our objective was to test that hypothesis by evaluating the veno-capillary dilution difference during mVLT in subjects with different hydration status. Materials and methods: In a prospective randomized crossover study, three mini fluid challenges were given to 12 healthy volunteers on two occasions. The subjects were either dehydrated or hydrated before the experiments. Results: In dehydrated subjects only, capillary plasma dilution was significantly lower than venous (P = 0.015, 0.005 and 0.006) after each mini fluid challenge. Conclusions: Veno-capillary dilution difference during mVLT depends on the hydration status. The mVLT method could possibly discriminate between the different states of hydration.http://www.sciencedirect.com/science/article/pii/S1010660X1400072XNoninvasive hemoglobinHydration statusCrystalloidInterstitial fluidMini volume loading test |
spellingShingle | Christer H. Svensen Edgaras Stankevičius Jacob Broms Vytautas Markevičius Audrius Andrijauskas Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers Medicina Noninvasive hemoglobin Hydration status Crystalloid Interstitial fluid Mini volume loading test |
title | Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers |
title_full | Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers |
title_fullStr | Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers |
title_full_unstemmed | Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers |
title_short | Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers |
title_sort | evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions a randomized crossover study in healthy volunteers |
topic | Noninvasive hemoglobin Hydration status Crystalloid Interstitial fluid Mini volume loading test |
url | http://www.sciencedirect.com/science/article/pii/S1010660X1400072X |
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