Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers

Background and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, ven...

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Main Authors: Christer H. Svensen, Edgaras Stankevičius, Jacob Broms, Vytautas Markevičius, Audrius Andrijauskas
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Medicina
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1010660X1400072X
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author Christer H. Svensen
Edgaras Stankevičius
Jacob Broms
Vytautas Markevičius
Audrius Andrijauskas
author_facet Christer H. Svensen
Edgaras Stankevičius
Jacob Broms
Vytautas Markevičius
Audrius Andrijauskas
author_sort Christer H. Svensen
collection DOAJ
description Background and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, venous plasma dilution induced by a fluid challenge is higher than in the capillaries, and that difference is diminished when the fluid challenge is given to more hydrated individuals. Our objective was to test that hypothesis by evaluating the veno-capillary dilution difference during mVLT in subjects with different hydration status. Materials and methods: In a prospective randomized crossover study, three mini fluid challenges were given to 12 healthy volunteers on two occasions. The subjects were either dehydrated or hydrated before the experiments. Results: In dehydrated subjects only, capillary plasma dilution was significantly lower than venous (P = 0.015, 0.005 and 0.006) after each mini fluid challenge. Conclusions: Veno-capillary dilution difference during mVLT depends on the hydration status. The mVLT method could possibly discriminate between the different states of hydration.
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spelling doaj.art-0182bcdcd9e74f61ab7e7921729662b72023-09-02T13:56:18ZengMDPI AGMedicina1010-660X2014-01-0150525526210.1016/j.medici.2014.09.007Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteersChrister H. Svensen0Edgaras Stankevičius1Jacob Broms2Vytautas Markevičius3Audrius Andrijauskas4Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, SwedenInstitute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaSection of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Stockholm, SwedenDepartment of Electronics Engineering, Kaunas University of Technology, Kaunas, LithuaniaClinic of Anaesthesiology and Intensive Care, Faculty of Medicine, Vilnius University, Vilnius, LithuaniaBackground and objective: A mini volume loading test (mVLT) was proposed for estimating hydration status and interstitial fluid accumulation during stepwise infusion of crystalloids. The method is based on both the transcapillary reflux model and the hypothesis that when subjects are dehydrated, venous plasma dilution induced by a fluid challenge is higher than in the capillaries, and that difference is diminished when the fluid challenge is given to more hydrated individuals. Our objective was to test that hypothesis by evaluating the veno-capillary dilution difference during mVLT in subjects with different hydration status. Materials and methods: In a prospective randomized crossover study, three mini fluid challenges were given to 12 healthy volunteers on two occasions. The subjects were either dehydrated or hydrated before the experiments. Results: In dehydrated subjects only, capillary plasma dilution was significantly lower than venous (P = 0.015, 0.005 and 0.006) after each mini fluid challenge. Conclusions: Veno-capillary dilution difference during mVLT depends on the hydration status. The mVLT method could possibly discriminate between the different states of hydration.http://www.sciencedirect.com/science/article/pii/S1010660X1400072XNoninvasive hemoglobinHydration statusCrystalloidInterstitial fluidMini volume loading test
spellingShingle Christer H. Svensen
Edgaras Stankevičius
Jacob Broms
Vytautas Markevičius
Audrius Andrijauskas
Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
Medicina
Noninvasive hemoglobin
Hydration status
Crystalloid
Interstitial fluid
Mini volume loading test
title Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
title_full Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
title_fullStr Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
title_full_unstemmed Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
title_short Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers
title_sort evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions a randomized crossover study in healthy volunteers
topic Noninvasive hemoglobin
Hydration status
Crystalloid
Interstitial fluid
Mini volume loading test
url http://www.sciencedirect.com/science/article/pii/S1010660X1400072X
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