Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease
Since people's lifestyles have changed, non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver condition globally. It can progress to cirrhosis and hepatocellular carcinoma (HCC), both of which pose major risks to people's health. Currently, the treatment of NAFL...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2023-07-01
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| Series: | Xiehe Yixue Zazhi |
| Subjects: | |
| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0710 |
| _version_ | 1797761281432748032 |
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| author | CHEN Danni WANG Shiling LU Hong ZHENG Ya WANG Yuping REN Qian |
| author_facet | CHEN Danni WANG Shiling LU Hong ZHENG Ya WANG Yuping REN Qian |
| author_sort | CHEN Danni |
| collection | DOAJ |
| description | Since people's lifestyles have changed, non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver condition globally. It can progress to cirrhosis and hepatocellular carcinoma (HCC), both of which pose major risks to people's health. Currently, the treatment of NAFLD is still based on lifestyle modification, glycemic and lipid control, and other risk factors, and there are no effective therapeutic drugs. Therefore, it is important to study the pathogenesis of NAFLD. Recent studies have shown that Helicobacter pylori (HP) infection is associated with the development of NAFLD, and HP infection may contribute to the development of NAFLD by inducing insulin resistance, altering the lipid profile, promoting oxidative stress, changing intestinal permeability, and regulating gene expression. Therefore, this paper reviews the correlation between HP infection and NAFLD and the potential pathogenesis of NAFLD due to HP infection, with the aim of providing new ideas for the diagnosis and treatment of NAFLD. |
| first_indexed | 2024-03-12T19:10:42Z |
| format | Article |
| id | doaj.art-018525ea3ce04afdbdd9b24947c767a8 |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-03-12T19:10:42Z |
| publishDate | 2023-07-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-018525ea3ce04afdbdd9b24947c767a82023-08-02T05:52:03ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812023-07-0114483383810.12290/xhyxzz.2022-0710Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver DiseaseCHEN DanniWANG ShilingLU HongZHENG YaWANG YupingREN QianSince people's lifestyles have changed, non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver condition globally. It can progress to cirrhosis and hepatocellular carcinoma (HCC), both of which pose major risks to people's health. Currently, the treatment of NAFLD is still based on lifestyle modification, glycemic and lipid control, and other risk factors, and there are no effective therapeutic drugs. Therefore, it is important to study the pathogenesis of NAFLD. Recent studies have shown that Helicobacter pylori (HP) infection is associated with the development of NAFLD, and HP infection may contribute to the development of NAFLD by inducing insulin resistance, altering the lipid profile, promoting oxidative stress, changing intestinal permeability, and regulating gene expression. Therefore, this paper reviews the correlation between HP infection and NAFLD and the potential pathogenesis of NAFLD due to HP infection, with the aim of providing new ideas for the diagnosis and treatment of NAFLD.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0710helicobacter pylorinon-alcoholic fatty liver diseaseinsulin resistanceintestinal flora |
| spellingShingle | CHEN Danni WANG Shiling LU Hong ZHENG Ya WANG Yuping REN Qian Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease Xiehe Yixue Zazhi helicobacter pylori non-alcoholic fatty liver disease insulin resistance intestinal flora |
| title | Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease |
| title_full | Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease |
| title_fullStr | Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease |
| title_full_unstemmed | Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease |
| title_short | Relationship and Potential Mechanism Between Helicobacter Pylori Infection and Non-alcoholic Fatty Liver Disease |
| title_sort | relationship and potential mechanism between helicobacter pylori infection and non alcoholic fatty liver disease |
| topic | helicobacter pylori non-alcoholic fatty liver disease insulin resistance intestinal flora |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0710 |
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