Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
Xue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-11-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/neuroinflammation-and-modulation-role-of-natural-products-after-spinal-peer-reviewed-fulltext-article-JIR |
| _version_ | 1818840282141032448 |
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| author | Wu X Yan Y Zhang Q |
| author_facet | Wu X Yan Y Zhang Q |
| author_sort | Wu X |
| collection | DOAJ |
| description | Xue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, The People’s Republic of ChinaCorrespondence: Qian Zhang Email zhangqian154@snnu.edu.cnAbstract: Spinal cord injury (SCI) is a severe traumatic injury of the central nervous system, characterized by neurological dysfunction and locomotor disability. Although the underlying pathological mechanism of SCI is complex and remains unclear, the important role of neuroinflammation has been gradually unveiled in recent years. The inflammation process after SCI involves disruption of the blood–spinal cord barrier (BSCB), activation of gliocytes, infiltration of peripheral macrophages, and feedback loops between different cells. Thus, our first aim is to illustrate pathogenesis, related cells and factors of neuroinflammation after SCI in this review. Due to the good bioactivity of natural products derived from plants and medicinal herbs, these widely exist as food, health-care products and drugs in our lives. In the inflammation after SCI, multiple natural products exert satisfactory effects. Therefore, the second aim of this review is to sum up the effects and mechanisms of 25 natural compounds and 7 extracts derived from plants or medicinal herbs on neuroinflammation after SCI. Clarification of the SCI inflammation mechanism and a summary of the related natural products is helpful for in-depth research and drug development.Keywords: spinal cord injury, neuroinflammation, blood-spinal cord barrier, microglia, astrocytes, natural products |
| first_indexed | 2024-12-19T04:07:42Z |
| format | Article |
| id | doaj.art-0186d64cc52d4b1d94cfca98caa02320 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-12-19T04:07:42Z |
| publishDate | 2021-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-0186d64cc52d4b1d94cfca98caa023202022-12-21T20:36:29ZengDove Medical PressJournal of Inflammation Research1178-70312021-11-01Volume 145713573770229Neuroinflammation and Modulation Role of Natural Products After Spinal Cord InjuryWu XYan YZhang QXue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, The People’s Republic of ChinaCorrespondence: Qian Zhang Email zhangqian154@snnu.edu.cnAbstract: Spinal cord injury (SCI) is a severe traumatic injury of the central nervous system, characterized by neurological dysfunction and locomotor disability. Although the underlying pathological mechanism of SCI is complex and remains unclear, the important role of neuroinflammation has been gradually unveiled in recent years. The inflammation process after SCI involves disruption of the blood–spinal cord barrier (BSCB), activation of gliocytes, infiltration of peripheral macrophages, and feedback loops between different cells. Thus, our first aim is to illustrate pathogenesis, related cells and factors of neuroinflammation after SCI in this review. Due to the good bioactivity of natural products derived from plants and medicinal herbs, these widely exist as food, health-care products and drugs in our lives. In the inflammation after SCI, multiple natural products exert satisfactory effects. Therefore, the second aim of this review is to sum up the effects and mechanisms of 25 natural compounds and 7 extracts derived from plants or medicinal herbs on neuroinflammation after SCI. Clarification of the SCI inflammation mechanism and a summary of the related natural products is helpful for in-depth research and drug development.Keywords: spinal cord injury, neuroinflammation, blood-spinal cord barrier, microglia, astrocytes, natural productshttps://www.dovepress.com/neuroinflammation-and-modulation-role-of-natural-products-after-spinal-peer-reviewed-fulltext-article-JIRspinal cord injuryneuroinflammationblood-spinal cord barriermicrogliaastrocytesnatural products |
| spellingShingle | Wu X Yan Y Zhang Q Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury Journal of Inflammation Research spinal cord injury neuroinflammation blood-spinal cord barrier microglia astrocytes natural products |
| title | Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury |
| title_full | Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury |
| title_fullStr | Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury |
| title_full_unstemmed | Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury |
| title_short | Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury |
| title_sort | neuroinflammation and modulation role of natural products after spinal cord injury |
| topic | spinal cord injury neuroinflammation blood-spinal cord barrier microglia astrocytes natural products |
| url | https://www.dovepress.com/neuroinflammation-and-modulation-role-of-natural-products-after-spinal-peer-reviewed-fulltext-article-JIR |
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