Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review
Diclofenac is one of the most popular non-steroidal anti-inflammatory drugs. Due to its over-the-counter availability and high consumption along with municipal and hospital wastewater, it enters the sewage treatment plant, where it is not completely degraded. This results in the appearance of diclof...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/13/2/412 |
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| author | Danuta Wojcieszyńska Karolina Łagoda Urszula Guzik |
| author_facet | Danuta Wojcieszyńska Karolina Łagoda Urszula Guzik |
| author_sort | Danuta Wojcieszyńska |
| collection | DOAJ |
| description | Diclofenac is one of the most popular non-steroidal anti-inflammatory drugs. Due to its over-the-counter availability and high consumption along with municipal and hospital wastewater, it enters the sewage treatment plant, where it is not completely degraded. This results in the appearance of diclofenac in the effluents from the treatment plant, and with them, it enters the surface waters. Due to its structure, it is characterised by its high resistance to degradation in the environment. At the same time, it shows documented acute and chronic toxicity to non-target organisms. For this reason, it is necessary to look for cheap solutions that enhance the degradation of diclofenac. The paper discusses both the pathways of microbiological degradation of this drug described so far, as well as modern systems of biocatalyst immobilisation, with a particular emphasis on laccases involved in the biotransformation of diclofenac. |
| first_indexed | 2024-03-11T09:00:31Z |
| format | Article |
| id | doaj.art-018906d92d6b4a468171f59654f30a89 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-11T09:00:31Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-018906d92d6b4a468171f59654f30a892023-11-16T19:42:48ZengMDPI AGCatalysts2073-43442023-02-0113241210.3390/catal13020412Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A ReviewDanuta Wojcieszyńska0Karolina Łagoda1Urszula Guzik2Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Science, University of Silesia in Katowice, Jagiellońska 28, 40-032 Katowice, PolandInstitute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Science, University of Silesia in Katowice, Jagiellońska 28, 40-032 Katowice, PolandInstitute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Science, University of Silesia in Katowice, Jagiellońska 28, 40-032 Katowice, PolandDiclofenac is one of the most popular non-steroidal anti-inflammatory drugs. Due to its over-the-counter availability and high consumption along with municipal and hospital wastewater, it enters the sewage treatment plant, where it is not completely degraded. This results in the appearance of diclofenac in the effluents from the treatment plant, and with them, it enters the surface waters. Due to its structure, it is characterised by its high resistance to degradation in the environment. At the same time, it shows documented acute and chronic toxicity to non-target organisms. For this reason, it is necessary to look for cheap solutions that enhance the degradation of diclofenac. The paper discusses both the pathways of microbiological degradation of this drug described so far, as well as modern systems of biocatalyst immobilisation, with a particular emphasis on laccases involved in the biotransformation of diclofenac.https://www.mdpi.com/2073-4344/13/2/412biodegradationdiclofenacimmobilizationtoxicitysewage treatmentlaccase |
| spellingShingle | Danuta Wojcieszyńska Karolina Łagoda Urszula Guzik Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review Catalysts biodegradation diclofenac immobilization toxicity sewage treatment laccase |
| title | Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review |
| title_full | Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review |
| title_fullStr | Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review |
| title_full_unstemmed | Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review |
| title_short | Diclofenac Biodegradation by Microorganisms and with Immobilised Systems—A Review |
| title_sort | diclofenac biodegradation by microorganisms and with immobilised systems a review |
| topic | biodegradation diclofenac immobilization toxicity sewage treatment laccase |
| url | https://www.mdpi.com/2073-4344/13/2/412 |
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