The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature
This review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10291 |
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| author | Anna Surówka Piotr Prowans Michał Żołnierczuk Marek Miśkiewicz Tomasz Wawrowski Marika Skodda Marta Markowska Karolina Kędzierska-Kapuza |
| author_facet | Anna Surówka Piotr Prowans Michał Żołnierczuk Marek Miśkiewicz Tomasz Wawrowski Marika Skodda Marta Markowska Karolina Kędzierska-Kapuza |
| author_sort | Anna Surówka |
| collection | DOAJ |
| description | This review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impact of immunosuppressive treatment on this relationship. Modern immunosuppressive treatment is based mainly on the use of calcineurin inhibitors, including cyclosporine A and tacrolimus. The use of these drugs may carry a number of side effects, specifically to the cardiovascular system. The scale and degree of long-term influence on the organism remains unclear, but a significant risk of complications for transplant recipients who take immunosuppressive drugs as part of their daily treatment is to be expected. Therefore, the knowledge on this subject should be expanded and the negative effects of post-transplant therapy minimized. Immunosuppressive therapy plays an important role in the expression and activation of tissue metalloproteinases and their specific inhibitors, which leads to many tissue changes. The presented study is a collection of research results on the effects of calcineurin inhibitors on the heart, with particular emphasis placed on the participation of MMP-2 and MMP-9. It is also an analysis of the effects of specific heart diseases on myocardial remodeling through inductive or inhibitory effects on matrix metalloproteinases and their inhibitors. |
| first_indexed | 2024-03-11T02:19:59Z |
| format | Article |
| id | doaj.art-0189a683aba24f3c8a2167a3d7120f39 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:19:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0189a683aba24f3c8a2167a3d7120f392023-11-18T10:51:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121029110.3390/ijms241210291The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of LiteratureAnna Surówka0Piotr Prowans1Michał Żołnierczuk2Marek Miśkiewicz3Tomasz Wawrowski4Marika Skodda5Marta Markowska6Karolina Kędzierska-Kapuza7Department of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Plastic, Endocrine and General Surgery, Pomeranian Medical University, 72-010 Szczecin, PolandDepartment of Gastroenterological Surgery and Transplantology, National Medical Institute of the Ministry of Interior Affairs and Administration, 02-507 Warsaw, PolandThis review focuses on the role of metalloproteinases in the pathogenesis of myocardial injury in various disease entities. It reveals how the expression and serum levels of metalloproteinases and their inhibitors change in many disease states. At the same time, the study offers a review of the impact of immunosuppressive treatment on this relationship. Modern immunosuppressive treatment is based mainly on the use of calcineurin inhibitors, including cyclosporine A and tacrolimus. The use of these drugs may carry a number of side effects, specifically to the cardiovascular system. The scale and degree of long-term influence on the organism remains unclear, but a significant risk of complications for transplant recipients who take immunosuppressive drugs as part of their daily treatment is to be expected. Therefore, the knowledge on this subject should be expanded and the negative effects of post-transplant therapy minimized. Immunosuppressive therapy plays an important role in the expression and activation of tissue metalloproteinases and their specific inhibitors, which leads to many tissue changes. The presented study is a collection of research results on the effects of calcineurin inhibitors on the heart, with particular emphasis placed on the participation of MMP-2 and MMP-9. It is also an analysis of the effects of specific heart diseases on myocardial remodeling through inductive or inhibitory effects on matrix metalloproteinases and their inhibitors.https://www.mdpi.com/1422-0067/24/12/10291metalloproteinasescalcineurin inhibitorscyclosporine Atacrolimus |
| spellingShingle | Anna Surówka Piotr Prowans Michał Żołnierczuk Marek Miśkiewicz Tomasz Wawrowski Marika Skodda Marta Markowska Karolina Kędzierska-Kapuza The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature International Journal of Molecular Sciences metalloproteinases calcineurin inhibitors cyclosporine A tacrolimus |
| title | The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature |
| title_full | The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature |
| title_fullStr | The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature |
| title_full_unstemmed | The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature |
| title_short | The Effect of Calcineurin Inhibitors on MMPs Activity in Heart and Their Side Effects—A Review of Literature |
| title_sort | effect of calcineurin inhibitors on mmps activity in heart and their side effects a review of literature |
| topic | metalloproteinases calcineurin inhibitors cyclosporine A tacrolimus |
| url | https://www.mdpi.com/1422-0067/24/12/10291 |
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