EXPERT expands prime editing efficiency and range of large fragment edits

EXPERT expands prime editing efficiency and range of large fragment edits

Abstract Prime editing systems (PEs) hold great promise in modern biotechnology. However, their editing range is limited as PEs can only modify the downstream sequences of the pegRNA nick. Here, we report the development of the extended prime editor system (EXPERT) to overcome this limitation by usi...

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Bibliographic Details
Main Authors: Youcai Xiong, Yinyu Su, Ruigao He, Xiaosong Han, Sheng Li, Minghuan Liu, Xiaoning Xi, Zijia Liu, Heng Wang, Shengsong Xie, Xuewen Xu, Kui Li, Jifeng Zhang, Jie Xu, Xinyun Li, Shuhong Zhao, Jinxue Ruan
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56734-9

Internet

https://doi.org/10.1038/s41467-025-56734-9

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