Single‐Cell Transcriptome Identifies Drug‐Resistance Signature and Immunosuppressive Microenvironment in Metastatic Small Cell Lung Cancer

Single‐Cell Transcriptome Identifies Drug‐Resistance Signature and Immunosuppressive Microenvironment in Metastatic Small Cell Lung Cancer

Abstract Small cell lung cancer (SCLC) is a deadly neuroendocrine malignancy with high metastasis. However, the heterogeneity of metastatic SCLC at the single‐cell level remains elusive. The single‐cell transcriptome of a total of 24 081 cells in metastatic lymph node samples from seven SCLC patient...

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Bibliographic Details
Main Authors: Jing Zhang, Haiping Zhang, Lele Zhang, Dianke Li, Mengfan Qi, Liping Zhang, Huansha Yu, Di Wang, Gening Jiang, Xujun Wang, Xianmin Zhu, Peng Zhang
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Advanced Genetics
Subjects:
heterogeneity
natural killer cells
single‐cell RNA sequencing
small cell lung cancer
tumor microenvironments
Online Access:https://doi.org/10.1002/ggn2.202100060

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