Biomarkers of Air-Blood Barrier Damage In COVID-19
The search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important for a successful treatment.The aim of the study was to examine the association of molecular biomarkers of air-blood barrier damage, sur...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2021-07-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/2075 |
| _version_ | 1797874175602327552 |
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| author | M. B. Khadzhieva A. S. Gracheva A. V. Ershov Yu. V. Chursinova V. A. Stepanov L. S. Avdeikina O. A. Grebenchikov A. S. Babkina A. K. Shabanov A. V. Tutelyan S. S. Petrikov A. N. Kuzovlev |
| author_facet | M. B. Khadzhieva A. S. Gracheva A. V. Ershov Yu. V. Chursinova V. A. Stepanov L. S. Avdeikina O. A. Grebenchikov A. S. Babkina A. K. Shabanov A. V. Tutelyan S. S. Petrikov A. N. Kuzovlev |
| author_sort | M. B. Khadzhieva |
| collection | DOAJ |
| description | The search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important for a successful treatment.The aim of the study was to examine the association of molecular biomarkers of air-blood barrier damage, surfactant proteins SP-A and SP-D and Club cell protein CC16, with the outcome of patients with COVID-19.Materials and methods. A cohort of 109 patients diagnosed with COVID-19 was retrospectively divided into two groups. Group 1 comprised survivor patients discharged from the ICU (w=90). Group 2 included the patients who did not survive (w=19). Association of disease outcome and SP-A, SP-D, and CC16 levels in blood serum, clinical, and laboratory data were examined taking into account the day of illness at the time of biomaterial collection.Results. The non-survivors had higher SP-A (from days 1 to 10 of symptoms onset) and lower CC16 (from days 11 to 20 of symptoms onset) levels vs survivors discharged from ICU. No significant differences in SP-D levels between the groups were found.Conclusion. According to the study results, the surfactant protein SP-A and Club cell protein CC16 are associated with increased COVID-19 mortality. |
| first_indexed | 2024-04-10T01:26:45Z |
| format | Article |
| id | doaj.art-018c7cd1799d4467848556d58df3a14e |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:26:45Z |
| publishDate | 2021-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-018c7cd1799d4467848556d58df3a14e2023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102021-07-01173163110.15360/1813-9779-2021-3-2-01792Biomarkers of Air-Blood Barrier Damage In COVID-19M. B. Khadzhieva0A. S. Gracheva1A. V. Ershov2Yu. V. Chursinova3V. A. Stepanov4L. S. Avdeikina5O. A. Grebenchikov6A. S. Babkina7A. K. Shabanov8A. V. Tutelyan9S. S. Petrikov10A. N. Kuzovlev11НИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР; Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России; Институт общей генетики им. Н.И. Вавилова, РАННИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР; Институт общей генетики им. Н.И. Вавилова, РАННИИ общей реаниматологии им. В.А. Неговского ФНКЦ РРМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоВороновская больница ДЗМНИИ общей реаниматологии им. В.А. Неговского ФНКЦ РРНИИ общей реаниматологии им. В. А. Неговского ФНКЦ РРНИИ общей реаниматологии им. В. А. Неговского ФНКЦ РР; НИИ скорой помощи им. Н. В. Склифосовского ДЗМЦентральный НИИ эпидемиологии РоспотребнадзораНИИ скорой помощи им. Н.В. Склифосовского ДЗМНИИ общей реаниматологии им. В.А. Неговского ФНКЦ РРThe search for sensitive and specific markers enabling timely identification of patients with a life-threatening novel coronavirus infection (COVID-19) is important for a successful treatment.The aim of the study was to examine the association of molecular biomarkers of air-blood barrier damage, surfactant proteins SP-A and SP-D and Club cell protein CC16, with the outcome of patients with COVID-19.Materials and methods. A cohort of 109 patients diagnosed with COVID-19 was retrospectively divided into two groups. Group 1 comprised survivor patients discharged from the ICU (w=90). Group 2 included the patients who did not survive (w=19). Association of disease outcome and SP-A, SP-D, and CC16 levels in blood serum, clinical, and laboratory data were examined taking into account the day of illness at the time of biomaterial collection.Results. The non-survivors had higher SP-A (from days 1 to 10 of symptoms onset) and lower CC16 (from days 11 to 20 of symptoms onset) levels vs survivors discharged from ICU. No significant differences in SP-D levels between the groups were found.Conclusion. According to the study results, the surfactant protein SP-A and Club cell protein CC16 are associated with increased COVID-19 mortality.https://www.reanimatology.com/rmt/article/view/2075сурфактантный белок sp-aсурфактантный белок sp-dбелок клеток клара cc16covid-19 |
| spellingShingle | M. B. Khadzhieva A. S. Gracheva A. V. Ershov Yu. V. Chursinova V. A. Stepanov L. S. Avdeikina O. A. Grebenchikov A. S. Babkina A. K. Shabanov A. V. Tutelyan S. S. Petrikov A. N. Kuzovlev Biomarkers of Air-Blood Barrier Damage In COVID-19 Общая реаниматология сурфактантный белок sp-a сурфактантный белок sp-d белок клеток клара cc16 covid-19 |
| title | Biomarkers of Air-Blood Barrier Damage In COVID-19 |
| title_full | Biomarkers of Air-Blood Barrier Damage In COVID-19 |
| title_fullStr | Biomarkers of Air-Blood Barrier Damage In COVID-19 |
| title_full_unstemmed | Biomarkers of Air-Blood Barrier Damage In COVID-19 |
| title_short | Biomarkers of Air-Blood Barrier Damage In COVID-19 |
| title_sort | biomarkers of air blood barrier damage in covid 19 |
| topic | сурфактантный белок sp-a сурфактантный белок sp-d белок клеток клара cc16 covid-19 |
| url | https://www.reanimatology.com/rmt/article/view/2075 |
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