Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems

Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems

Summary: Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying chemically induced cell-fate reprogramming remain unclear. Here, a t...

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Bibliographic Details
Main Authors: Jun Li, Yunfei Bai, Yang Liu, Zhongya Song, Yong Yang, Yang Zhao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005776

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