Experimental evidence of a limited impact of new-generation perfluoroalkyl substance C6O4 on differentiating human dopaminergic neurons from induced pluripotent stem cells

Experimental evidence of a limited impact of new-generation perfluoroalkyl substance C6O4 on differentiating human dopaminergic neurons from induced pluripotent stem cells

Perfluoroalkyl substances (PFASs) are persistent pollutants, raising concerns for human health. Legacy PFAS perfluoro-octanoic acid (PFOA) accumulate in brains of people at high environmental exposure, especially in areas enriched with dopaminergic neurons (DN). In vitro exposure to 10 ng/mL PFOA fo...

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Bibliographic Details
Main Authors:	Andrea Di Nisio, Marta Trevisan, Stefano Dall’Acqua, Micaela Pannella, Claudia Pappalardo, Alberto Ferlin, Carlo Foresta, Luca De Toni
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Toxicology Reports
Subjects:	Endocrine disruptors Perfluoroalkyl substances Dopaminergic neuron Human induced pluripotent stem cells Tyrosine hydroxylase
Online Access:	http://www.sciencedirect.com/science/article/pii/S221475002200230X

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