The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease

Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divi...

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Main Authors: Recep Özmerdivenli, Ferhat Şirinyıldız, Ayşe Nur Yıldırım
Format: Article
Language:English
Published: Duzce University 2023-08-01
Series:Düzce Tıp Fakültesi Dergisi
Subjects:
Online Access:https://dergipark.org.tr/en/download/article-file/3160377
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author Recep Özmerdivenli
Ferhat Şirinyıldız
Ayşe Nur Yıldırım
author_facet Recep Özmerdivenli
Ferhat Şirinyıldız
Ayşe Nur Yıldırım
author_sort Recep Özmerdivenli
collection DOAJ
description Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP (25 ng/kg) to the RT+VIP group, and rotenone and naringenin (10 mg/kg) to the RT+NG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinson's model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RT+NG (p=0.023), malondialdehyde (MDA) levels both in the RT+VIP (p=0.039) and RT+NG (p=0.032), and superoxide dismutase (SOD) inhibition in the RT+VIP (p=0.042) groups decreased significantly, the 8-OHdG levels in the RT+VIP (p=0.042) and RT+NG (p=0.034) groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinson's disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinson's disease.
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spelling doaj.art-01908a11db1b4f16b94b4b28f9adc99a2023-12-03T09:55:49ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2023-08-0125217918410.18678/dtfd.130125297The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's DiseaseRecep Özmerdivenli0Ferhat Şirinyıldız1Ayşe Nur Yıldırım2AYDIN ADNAN MENDERES UNIVERSITY, SCHOOL OF MEDICINEAYDIN ADNAN MENDERES UNIVERSITY, SCHOOL OF MEDICINEAYDIN ADNAN MENDERES UNIVERSITYAim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP (25 ng/kg) to the RT+VIP group, and rotenone and naringenin (10 mg/kg) to the RT+NG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinson's model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RT+NG (p=0.023), malondialdehyde (MDA) levels both in the RT+VIP (p=0.039) and RT+NG (p=0.032), and superoxide dismutase (SOD) inhibition in the RT+VIP (p=0.042) groups decreased significantly, the 8-OHdG levels in the RT+VIP (p=0.042) and RT+NG (p=0.034) groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinson's disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinson's disease.https://dergipark.org.tr/en/download/article-file/3160377parkinson hastalığırotenonsıçanlarvazointestinal peptitparkinsonratsrotenonevasointestinal peptide
spellingShingle Recep Özmerdivenli
Ferhat Şirinyıldız
Ayşe Nur Yıldırım
The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
Düzce Tıp Fakültesi Dergisi
parkinson hastalığı
rotenon
sıçanlar
vazointestinal peptit
parkinson
rats
rotenone
vasointestinal peptide
title The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
title_full The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
title_fullStr The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
title_full_unstemmed The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
title_short The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
title_sort effects of vasointestinal peptide and naringenin on rotenone induced experimental model of parkinson s disease
topic parkinson hastalığı
rotenon
sıçanlar
vazointestinal peptit
parkinson
rats
rotenone
vasointestinal peptide
url https://dergipark.org.tr/en/download/article-file/3160377
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