The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease
Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divi...
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Format: | Article |
Language: | English |
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Duzce University
2023-08-01
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Series: | Düzce Tıp Fakültesi Dergisi |
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Online Access: | https://dergipark.org.tr/en/download/article-file/3160377 |
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author | Recep Özmerdivenli Ferhat Şirinyıldız Ayşe Nur Yıldırım |
author_facet | Recep Özmerdivenli Ferhat Şirinyıldız Ayşe Nur Yıldırım |
author_sort | Recep Özmerdivenli |
collection | DOAJ |
description | Aim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats.
Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP (25 ng/kg) to the RT+VIP group, and rotenone and naringenin (10 mg/kg) to the RT+NG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinson's model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples.
Results: In comparison to the RT group, while the alpha-sync level in the RT+NG (p=0.023), malondialdehyde (MDA) levels both in the RT+VIP (p=0.039) and RT+NG (p=0.032), and superoxide dismutase (SOD) inhibition in the RT+VIP (p=0.042) groups decreased significantly, the 8-OHdG levels in the RT+VIP (p=0.042) and RT+NG (p=0.034) groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied.
Conclusion: According to the results obtained, the symptoms of Parkinson's disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinson's disease. |
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institution | Directory Open Access Journal |
issn | 1307-671X |
language | English |
last_indexed | 2024-03-09T06:59:41Z |
publishDate | 2023-08-01 |
publisher | Duzce University |
record_format | Article |
series | Düzce Tıp Fakültesi Dergisi |
spelling | doaj.art-01908a11db1b4f16b94b4b28f9adc99a2023-12-03T09:55:49ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2023-08-0125217918410.18678/dtfd.130125297The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's DiseaseRecep Özmerdivenli0Ferhat Şirinyıldız1Ayşe Nur Yıldırım2AYDIN ADNAN MENDERES UNIVERSITY, SCHOOL OF MEDICINEAYDIN ADNAN MENDERES UNIVERSITY, SCHOOL OF MEDICINEAYDIN ADNAN MENDERES UNIVERSITYAim: The aim of this study was to evaluate the intraperitoneal administration of naringenin and vasointestinal peptide (VIP), which are shown effective in various scientific studies, in terms of anti-Parkinsonian activity in rats. Material and Methods: Forty-eight Wistar albino female rats were divided into 4 groups. No intervention was made in the control group, rotenone was given to the RT group, rotenone and VIP (25 ng/kg) to the RT+VIP group, and rotenone and naringenin (10 mg/kg) to the RT+NG group. All treatments were administered intraperitoneally for 14 days. The hole and board method was used to show the effects of the Parkinson's model on behavior. On the last day of the experiment, motor tests were carried out with the hole and board apparatus. After the study was completed, biochemical analyzes were performed from brain tissue samples. Results: In comparison to the RT group, while the alpha-sync level in the RT+NG (p=0.023), malondialdehyde (MDA) levels both in the RT+VIP (p=0.039) and RT+NG (p=0.032), and superoxide dismutase (SOD) inhibition in the RT+VIP (p=0.042) groups decreased significantly, the 8-OHdG levels in the RT+VIP (p=0.042) and RT+NG (p=0.034) groups increased significantly. Statistically significant improvement was found both in biochemical and motor activities with the VIP and naringenin treatments applied. Conclusion: According to the results obtained, the symptoms of Parkinson's disease were formed biochemically by rotenone application. The administration of VIP and naringenin treatments has shown positive effects experimentally and has been promising as an adjunct treatment element in the fight against Parkinson's disease.https://dergipark.org.tr/en/download/article-file/3160377parkinson hastalığırotenonsıçanlarvazointestinal peptitparkinsonratsrotenonevasointestinal peptide |
spellingShingle | Recep Özmerdivenli Ferhat Şirinyıldız Ayşe Nur Yıldırım The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease Düzce Tıp Fakültesi Dergisi parkinson hastalığı rotenon sıçanlar vazointestinal peptit parkinson rats rotenone vasointestinal peptide |
title | The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease |
title_full | The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease |
title_fullStr | The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease |
title_full_unstemmed | The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease |
title_short | The Effects of Vasointestinal Peptide and Naringenin on Rotenone-Induced Experimental Model of Parkinson's Disease |
title_sort | effects of vasointestinal peptide and naringenin on rotenone induced experimental model of parkinson s disease |
topic | parkinson hastalığı rotenon sıçanlar vazointestinal peptit parkinson rats rotenone vasointestinal peptide |
url | https://dergipark.org.tr/en/download/article-file/3160377 |
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