Lactoferrin Disaggregates Pneumococcal Biofilms and Inhibits Acquisition of Resistance Through Its DNase Activity

Lactoferrin Disaggregates Pneumococcal Biofilms and Inhibits Acquisition of Resistance Through Its DNase Activity

Streptococcus pneumoniae colonizes the upper airways of children and the elderly. Colonization progresses to persistent carriage when S. pneumoniae forms biofilms, a feature required for the development of pneumococcal disease. Nasopharyngeal biofilms are structured with a matrix that includes extra...

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Bibliographic Details
Main Authors: Uriel A. Angulo-Zamudio, Jorge E. Vidal, Kamran Nazmi, Jan G. M. Bolscher, Claudia Leon-Sicairos, Brenda S. Antezana, Adrián Canizalez-Roman, Nidia León-Sicairos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
lactoferrin
disaggregates
pneumococcal biofilms
DNAse activity
resistance acquisition
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02386/full

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