Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study
Altered gut microbiota has been reported in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Previous research has suggested that specific bacterial species might be associated with the decline of cognitive function. However, the evidence was insufficient, and the resul...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/19/3959 |
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| author | Zheng Zhu Xiaoxi Ma Jie Wu Zhenxu Xiao Wanqing Wu Saineng Ding Li Zheng Xiaoniu Liang Jianfeng Luo Ding Ding Qianhua Zhao |
| author_facet | Zheng Zhu Xiaoxi Ma Jie Wu Zhenxu Xiao Wanqing Wu Saineng Ding Li Zheng Xiaoniu Liang Jianfeng Luo Ding Ding Qianhua Zhao |
| author_sort | Zheng Zhu |
| collection | DOAJ |
| description | Altered gut microbiota has been reported in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Previous research has suggested that specific bacterial species might be associated with the decline of cognitive function. However, the evidence was insufficient, and the results were inconsistent. To determine whether there is an alteration of gut microbiota in patients with MCI and AD and to investigate its correlation with clinical characteristics, the fecal samples from 94 cognitively normal controls (NC), 125 participants with MCI, and 83 patients with AD were collected and analyzed by 16S ribosomal RNA sequencing. The overall microbial compositions and specific taxa were compared. The clinical relevance was analyzed. There was no significant overall difference in the alpha and beta diversity among the three groups. Patients with AD or MCI had increased bacterial taxa including Erysipelatoclostridiaceae, Erysipelotrichales, Patescibacteria, Saccharimonadales, and Saccharimonadia, compared with NC group (<i>p</i> < 0.05), which were positively correlated with APOE 4 carrier status and Clinical Dementia Rating (correlation coefficient: 0.11~0.31, <i>p</i> < 0.05), and negatively associated with memory (correlation coefficient: −0.19~−0.16, <i>p</i> < 0.01). Our results supported the hypothesis that intestinal microorganisms change in MCI and AD. The alteration in specific taxa correlated closely with clinical manifestations, indicating the potential role in AD pathogenesis. |
| first_indexed | 2024-03-09T21:19:25Z |
| format | Article |
| id | doaj.art-01944cced506419f89bee50d1321de28 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T21:19:25Z |
| publishDate | 2022-09-01 |
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| series | Nutrients |
| spelling | doaj.art-01944cced506419f89bee50d1321de282023-11-23T21:23:12ZengMDPI AGNutrients2072-66432022-09-011419395910.3390/nu14193959Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory StudyZheng Zhu0Xiaoxi Ma1Jie Wu2Zhenxu Xiao3Wanqing Wu4Saineng Ding5Li Zheng6Xiaoniu Liang7Jianfeng Luo8Ding Ding9Qianhua Zhao10Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaAltered gut microbiota has been reported in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Previous research has suggested that specific bacterial species might be associated with the decline of cognitive function. However, the evidence was insufficient, and the results were inconsistent. To determine whether there is an alteration of gut microbiota in patients with MCI and AD and to investigate its correlation with clinical characteristics, the fecal samples from 94 cognitively normal controls (NC), 125 participants with MCI, and 83 patients with AD were collected and analyzed by 16S ribosomal RNA sequencing. The overall microbial compositions and specific taxa were compared. The clinical relevance was analyzed. There was no significant overall difference in the alpha and beta diversity among the three groups. Patients with AD or MCI had increased bacterial taxa including Erysipelatoclostridiaceae, Erysipelotrichales, Patescibacteria, Saccharimonadales, and Saccharimonadia, compared with NC group (<i>p</i> < 0.05), which were positively correlated with APOE 4 carrier status and Clinical Dementia Rating (correlation coefficient: 0.11~0.31, <i>p</i> < 0.05), and negatively associated with memory (correlation coefficient: −0.19~−0.16, <i>p</i> < 0.01). Our results supported the hypothesis that intestinal microorganisms change in MCI and AD. The alteration in specific taxa correlated closely with clinical manifestations, indicating the potential role in AD pathogenesis.https://www.mdpi.com/2072-6643/14/19/3959gut microbiomeAlzheimer’s diseasemild cognitive impairment16S ribosomal RNA |
| spellingShingle | Zheng Zhu Xiaoxi Ma Jie Wu Zhenxu Xiao Wanqing Wu Saineng Ding Li Zheng Xiaoniu Liang Jianfeng Luo Ding Ding Qianhua Zhao Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study Nutrients gut microbiome Alzheimer’s disease mild cognitive impairment 16S ribosomal RNA |
| title | Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study |
| title_full | Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study |
| title_fullStr | Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study |
| title_full_unstemmed | Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study |
| title_short | Altered Gut Microbiota and Its Clinical Relevance in Mild Cognitive Impairment and Alzheimer’s Disease: Shanghai Aging Study and Shanghai Memory Study |
| title_sort | altered gut microbiota and its clinical relevance in mild cognitive impairment and alzheimer s disease shanghai aging study and shanghai memory study |
| topic | gut microbiome Alzheimer’s disease mild cognitive impairment 16S ribosomal RNA |
| url | https://www.mdpi.com/2072-6643/14/19/3959 |
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