Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series
Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo...
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MDPI AG
2020-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/12/4042 |
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| author | Luisa Limongelli Angela Tempesta Dorina Lauritano Eugenio Maiorano Giuseppe Ingravallo Gianfranco Favia Saverio Capodiferro |
| author_facet | Luisa Limongelli Angela Tempesta Dorina Lauritano Eugenio Maiorano Giuseppe Ingravallo Gianfranco Favia Saverio Capodiferro |
| author_sort | Luisa Limongelli |
| collection | DOAJ |
| description | Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory. |
| first_indexed | 2024-03-10T14:04:32Z |
| format | Article |
| id | doaj.art-01954332ad5e460894c4d74e73d08360 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:04:32Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-01954332ad5e460894c4d74e73d083602023-11-21T00:46:50ZengMDPI AGJournal of Clinical Medicine2077-03832020-12-01912404210.3390/jcm9124042Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case SeriesLuisa Limongelli0Angela Tempesta1Dorina Lauritano2Eugenio Maiorano3Giuseppe Ingravallo4Gianfranco Favia5Saverio Capodiferro6Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyCentre of Neuroscience of Milan, Department of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, ItalyDepartment of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, ItalyPeripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory.https://www.mdpi.com/2077-0383/9/12/4042perhipheral giant cell granulomaprimary hyperparathyroidismoral pathologyhead and neck pathology |
| spellingShingle | Luisa Limongelli Angela Tempesta Dorina Lauritano Eugenio Maiorano Giuseppe Ingravallo Gianfranco Favia Saverio Capodiferro Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series Journal of Clinical Medicine perhipheral giant cell granuloma primary hyperparathyroidism oral pathology head and neck pathology |
| title | Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series |
| title_full | Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series |
| title_fullStr | Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series |
| title_full_unstemmed | Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series |
| title_short | Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series |
| title_sort | peripheral giant cell granuloma of the jaws as first sign of primary hyperparathyroidism a case series |
| topic | perhipheral giant cell granuloma primary hyperparathyroidism oral pathology head and neck pathology |
| url | https://www.mdpi.com/2077-0383/9/12/4042 |
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