Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Abstract Background The interplay of epigenetic processes and the intestinal microbiota may play an important role in intestinal development and homeostasis. Previous studies have established that the microbiota regulates a large proportion of the intestinal epithelial transcriptome in the adult hos...

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Main Authors: Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, Priyadarshini Kachroo, Anne Luzius, Marlene Jentzsch, Ateequr Rehman, Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John F. Baines, Stefan Schreiber, Andre Franke, Joachim L. Schultze, Fredrik Bäckhed, Philip Rosenstiel
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Genome Medicine
Subjects:
Microbiota
Intestinal epithelial cell
Epigenetics
Methylation
Transcriptomics
Online Access:http://link.springer.com/article/10.1186/s13073-018-0534-5

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