Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures
Purpose: This study was performed to investigate the incidence of thrombophilic gene mutations in repeated assisted reproductive technology (ART) failures. Methods: The prevalence of mutated genes in the patients with a history of three or more previous ART failures was compared with the patients wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2012-08-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-233.pdf |
| _version_ | 1818483056710778880 |
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| author | Kobra Hamdi Maryam Vaezi Behrooz Dagigazar Mahzad Mehrzad Sadagiani Laya Farzadi Maryam Pashaei-Asl |
| author_facet | Kobra Hamdi Maryam Vaezi Behrooz Dagigazar Mahzad Mehrzad Sadagiani Laya Farzadi Maryam Pashaei-Asl |
| author_sort | Kobra Hamdi |
| collection | DOAJ |
| description | Purpose: This study was performed to investigate the incidence of thrombophilic gene mutations in repeated assisted reproductive technology (ART) failures. Methods: The prevalence of mutated genes in the patients with a history of three or more previous ART failures was compared with the patients with a history of successful pregnancy following ARTs. The study group included 70 patients, 34 with three or more previously failed ARTs (A) and control group consisted of 36 patients with successful pregnancy following ARTs (B). All patients were tested for the presence of mutated thrombophilic genes including factor V Leiden (FVL), Methylenetetrahydrofolate reductase (MTHFR) and Prothrombin (G20210A) using real-time polymerase chain reaction (RT- PCR). Results: Mutation of FVL gene was detected in 5.9% women of group A (2 of 34) compared with 2.8% women (1 of 36) of control group (P = 0.6). Mutation of MTHFR gene was found in 35.3% (12 cases) as compared with 50% (18 cases) of control (35.3% versus 50%; P = 0.23). Regarding Prothrombin, only control group had 5.6% mutation (P = 0.49). No significant differences were detected in the incidences of FVL, Prothrombin and MTHFR in the study group A compared with the control group B. Conclusion: The obtained results suggest that thrombophilia does not have a significant effect in ART failures. |
| first_indexed | 2024-12-10T11:55:18Z |
| format | Article |
| id | doaj.art-0195d6defdab4deca2bfe1947c631fff |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-10T11:55:18Z |
| publishDate | 2012-08-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-0195d6defdab4deca2bfe1947c631fff2022-12-22T01:49:49ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082012-08-0122233237Association between Thrombophilia and Repeated Assisted Reproductive Technology FailuresKobra HamdiMaryam VaeziBehrooz DagigazarMahzad Mehrzad SadagianiLaya FarzadiMaryam Pashaei-AslPurpose: This study was performed to investigate the incidence of thrombophilic gene mutations in repeated assisted reproductive technology (ART) failures. Methods: The prevalence of mutated genes in the patients with a history of three or more previous ART failures was compared with the patients with a history of successful pregnancy following ARTs. The study group included 70 patients, 34 with three or more previously failed ARTs (A) and control group consisted of 36 patients with successful pregnancy following ARTs (B). All patients were tested for the presence of mutated thrombophilic genes including factor V Leiden (FVL), Methylenetetrahydrofolate reductase (MTHFR) and Prothrombin (G20210A) using real-time polymerase chain reaction (RT- PCR). Results: Mutation of FVL gene was detected in 5.9% women of group A (2 of 34) compared with 2.8% women (1 of 36) of control group (P = 0.6). Mutation of MTHFR gene was found in 35.3% (12 cases) as compared with 50% (18 cases) of control (35.3% versus 50%; P = 0.23). Regarding Prothrombin, only control group had 5.6% mutation (P = 0.49). No significant differences were detected in the incidences of FVL, Prothrombin and MTHFR in the study group A compared with the control group B. Conclusion: The obtained results suggest that thrombophilia does not have a significant effect in ART failures.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-233.pdfMutationThrombophiliaARTPregnancy |
| spellingShingle | Kobra Hamdi Maryam Vaezi Behrooz Dagigazar Mahzad Mehrzad Sadagiani Laya Farzadi Maryam Pashaei-Asl Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures Advanced Pharmaceutical Bulletin Mutation Thrombophilia ART Pregnancy |
| title | Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures |
| title_full | Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures |
| title_fullStr | Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures |
| title_full_unstemmed | Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures |
| title_short | Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures |
| title_sort | association between thrombophilia and repeated assisted reproductive technology failures |
| topic | Mutation Thrombophilia ART Pregnancy |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-233.pdf |
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