Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments
(1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP...
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| Format: | Article |
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MDPI AG
2018-10-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/18/10/3565 |
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| author | Flurin Pfiffner Lukas Prochazka Ivo Dobrev Karina Klein Patrizia Sulser Dominik Péus Jae Hoon Sim Adrian Dalbert Christof Röösli Dominik Obrist Alexander Huber |
| author_facet | Flurin Pfiffner Lukas Prochazka Ivo Dobrev Karina Klein Patrizia Sulser Dominik Péus Jae Hoon Sim Adrian Dalbert Christof Röösli Dominik Obrist Alexander Huber |
| author_sort | Flurin Pfiffner |
| collection | DOAJ |
| description | (1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP measurements in a large animal. The ICAR was designed not only to be used in chronic animal experiments but also as a microphone for totally implantable cochlear implants (TICI). (2) Methods: The ICAR concept was based on a commercial MEMS condenser microphone customized with a protective diaphragm that provided a seal and optimized geometry for accessing the cochlea. The ICAR was validated under laboratory conditions and using in-vivo experiments in sheep. (3) Results: For the first time acute ICSP measurements were successfully performed in a live specimen that is representative of the anatomy and physiology of the human. Data obtained are in agreement with published data from cadavers. The surgeons reported high levels of ease of use and satisfaction with the system design. (4) Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI. |
| first_indexed | 2024-04-13T08:16:27Z |
| format | Article |
| id | doaj.art-01965f9aa0eb4c23a77abd7132f0a62d |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T08:16:27Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-01965f9aa0eb4c23a77abd7132f0a62d2022-12-22T02:54:46ZengMDPI AGSensors1424-82202018-10-011810356510.3390/s18103565s18103565Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal ExperimentsFlurin Pfiffner0Lukas Prochazka1Ivo Dobrev2Karina Klein3Patrizia Sulser4Dominik Péus5Jae Hoon Sim6Adrian Dalbert7Christof Röösli8Dominik Obrist9Alexander Huber10Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandVetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandARTORG Center, University of Bern, 3010 Bern, SwitzerlandDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland(1) Background: The measurement of intracochlear sound pressure (ICSP) is relevant to obtain better understanding of the biomechanics of hearing. The goal of this work was a proof of concept of a partially implantable intracochlear acoustic receiver (ICAR) fulfilling all requirements for acute ICSP measurements in a large animal. The ICAR was designed not only to be used in chronic animal experiments but also as a microphone for totally implantable cochlear implants (TICI). (2) Methods: The ICAR concept was based on a commercial MEMS condenser microphone customized with a protective diaphragm that provided a seal and optimized geometry for accessing the cochlea. The ICAR was validated under laboratory conditions and using in-vivo experiments in sheep. (3) Results: For the first time acute ICSP measurements were successfully performed in a live specimen that is representative of the anatomy and physiology of the human. Data obtained are in agreement with published data from cadavers. The surgeons reported high levels of ease of use and satisfaction with the system design. (4) Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI.http://www.mdpi.com/1424-8220/18/10/3565acoustic receiverauditory systembiomedical measurementBioMEMScochleaearhydrophoneimplantable microphoneimplantable sensorintracochlear sound pressuresheeptotally implantable cochlear implant |
| spellingShingle | Flurin Pfiffner Lukas Prochazka Ivo Dobrev Karina Klein Patrizia Sulser Dominik Péus Jae Hoon Sim Adrian Dalbert Christof Röösli Dominik Obrist Alexander Huber Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments Sensors acoustic receiver auditory system biomedical measurement BioMEMS cochlea ear hydrophone implantable microphone implantable sensor intracochlear sound pressure sheep totally implantable cochlear implant |
| title | Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments |
| title_full | Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments |
| title_fullStr | Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments |
| title_full_unstemmed | Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments |
| title_short | Proof of Concept for an Intracochlear Acoustic Receiver for Use in Acute Large Animal Experiments |
| title_sort | proof of concept for an intracochlear acoustic receiver for use in acute large animal experiments |
| topic | acoustic receiver auditory system biomedical measurement BioMEMS cochlea ear hydrophone implantable microphone implantable sensor intracochlear sound pressure sheep totally implantable cochlear implant |
| url | http://www.mdpi.com/1424-8220/18/10/3565 |
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