HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE
In the search to develop new cardioprotective therapies, considerable interest has focussed on approaches for targeting the biological functions of high-density lipoproteins (HDL). This is based on data from population and animal studies demonstrating a potentially protective impact of HDL on cardio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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European Medical Journal
2020-10-01
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| Series: | European Medical Journal Cardiology |
| Subjects: | |
| Online Access: | https://www.emjreviews.com/cardiology/article/high-density-lipoproteins-and-cardiovascular-disease/ |
| _version_ | 1819161498645168128 |
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| author | Stephen J. Nicholls Hannah Brown Kristen Bubb |
| author_facet | Stephen J. Nicholls Hannah Brown Kristen Bubb |
| author_sort | Stephen J. Nicholls |
| collection | DOAJ |
| description | In the search to develop new cardioprotective therapies, considerable interest has focussed on approaches for targeting the biological functions of high-density lipoproteins (HDL). This is based on data from population and animal studies demonstrating a potentially protective impact of HDL on cardiovascular risk. The findings of recent clinical trials of a range of therapeutic interventions aimed at promoting HDL have been disappointing and raise considerable uncertainty regarding the potential utility of this target. More recent evidence has highlighted the importance of HDL functionality, which may ultimately be important in terms of its association with cardiovascular risk. This has led to ongoing efforts to develop new risk markers and therapeutics focussing on HDL quality as opposed to quantity. The evidence supporting a protective role for HDL and findings of clinical trials of HDL-targeted therapies are reviewed here. |
| first_indexed | 2024-12-22T17:13:18Z |
| format | Article |
| id | doaj.art-019867d1cc884f429d4b71a0927dfa4a |
| institution | Directory Open Access Journal |
| issn | 2054-3174 |
| language | English |
| last_indexed | 2024-12-22T17:13:18Z |
| publishDate | 2020-10-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Cardiology |
| spelling | doaj.art-019867d1cc884f429d4b71a0927dfa4a2022-12-21T18:19:00ZengEuropean Medical JournalEuropean Medical Journal Cardiology2054-31742020-10-018110.33590/emjcardiol/20-00038.HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASEStephen J. Nicholls0Hannah Brown1Kristen Bubb2Monash Cardiovascular Research Centre, Monash University and Biomedical Discovery Institute, Monash University, Melbourne, AustraliaMonash Cardiovascular Research Centre, Monash University and Biomedical Discovery Institute, Monash University, Melbourne, AustraliaMonash Cardiovascular Research Centre, Monash University and Biomedical Discovery Institute, Monash University, Melbourne, AustraliaIn the search to develop new cardioprotective therapies, considerable interest has focussed on approaches for targeting the biological functions of high-density lipoproteins (HDL). This is based on data from population and animal studies demonstrating a potentially protective impact of HDL on cardiovascular risk. The findings of recent clinical trials of a range of therapeutic interventions aimed at promoting HDL have been disappointing and raise considerable uncertainty regarding the potential utility of this target. More recent evidence has highlighted the importance of HDL functionality, which may ultimately be important in terms of its association with cardiovascular risk. This has led to ongoing efforts to develop new risk markers and therapeutics focussing on HDL quality as opposed to quantity. The evidence supporting a protective role for HDL and findings of clinical trials of HDL-targeted therapies are reviewed here.https://www.emjreviews.com/cardiology/article/high-density-lipoproteins-and-cardiovascular-disease/high-density lipoproteinscardiovascular risklipid-modifying strategieshigh-density lipoprotein infusionscholesteryl ester transfer protein inhibitorsadditional high-density lipoprotein-targeted strategiescardiovascular diseasedysfunctional high-density lipoproteins |
| spellingShingle | Stephen J. Nicholls Hannah Brown Kristen Bubb HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE European Medical Journal Cardiology high-density lipoproteins cardiovascular risk lipid-modifying strategies high-density lipoprotein infusions cholesteryl ester transfer protein inhibitors additional high-density lipoprotein-targeted strategies cardiovascular disease dysfunctional high-density lipoproteins |
| title | HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE |
| title_full | HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE |
| title_fullStr | HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE |
| title_full_unstemmed | HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE |
| title_short | HIGH-DENSITY LIPOPROTEINS AND CARDIOVASCULAR DISEASE |
| title_sort | high density lipoproteins and cardiovascular disease |
| topic | high-density lipoproteins cardiovascular risk lipid-modifying strategies high-density lipoprotein infusions cholesteryl ester transfer protein inhibitors additional high-density lipoprotein-targeted strategies cardiovascular disease dysfunctional high-density lipoproteins |
| url | https://www.emjreviews.com/cardiology/article/high-density-lipoproteins-and-cardiovascular-disease/ |
| work_keys_str_mv | AT stephenjnicholls highdensitylipoproteinsandcardiovasculardisease AT hannahbrown highdensitylipoproteinsandcardiovasculardisease AT kristenbubb highdensitylipoproteinsandcardiovasculardisease |