Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy
IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity. It may be related to differences in plasma renin-angiotensin-aldosterone components between monochorionic and dichorionic twin pregnancies. The s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1329025/full |
| _version_ | 1797362440702263296 |
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| author | Paweł Pietruski Katarzyna Kosińska-Kaczyńska Agnieszka Osińska Magdalena Zgliczyńska Kinga Żebrowska Katarzyna Popko Anna Stelmaszczyk-Emmel |
| author_facet | Paweł Pietruski Katarzyna Kosińska-Kaczyńska Agnieszka Osińska Magdalena Zgliczyńska Kinga Żebrowska Katarzyna Popko Anna Stelmaszczyk-Emmel |
| author_sort | Paweł Pietruski |
| collection | DOAJ |
| description | IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity. It may be related to differences in plasma renin-angiotensin-aldosterone components between monochorionic and dichorionic twin pregnancies. The study aimed to analyze the plasma ANG II and ANG 1-7 concentrations in women with monochorionic and dichorionic twin gestation.MethodsA prospective observational study included 79 women between 32 and 34 weeks of gestation with twin pregnancy (31 with monochorionic gestation and 48 with dichorionic gestation). Angiotensin II and angiotensin 1-7 concentrations were measured in the collected blood samples.ResultsNo significant differences were observed in angiotensin II concentrations between the dichorionic and monochorionic group with significantly higher levels of angiotensin 1-7 being observed in the dichorionic group. Angiotensin 1-7 level was higher than angiotensin II in 20 women (64.5%) in the monochorionic group and in 42 women (87.5%, p=0.01) in the dichorionic group. Higher plasma concentrations of angiotensin II and lower concentrations of angiotensin 1-7 were found in 5 women with gestational hypertension and in 3 with preeclampsia compared to normotensive women.DiscussionIt is the first study investigating angiotensin II and angiotensin 1-7 in twin pregnancies regarding chorionicity. Our results showed that plasma angiotensin 1-7 concentration was related to chorionicity, while plasma angiotensin II level was not. In most women with twin gestation angiotensin 1-7 concentration exceeded the concentration of angiotensin II. A switch in the relation between angiotensin II and angiotensin 1-7 was observed in hypertensive pregnant women. |
| first_indexed | 2024-03-08T16:07:01Z |
| format | Article |
| id | doaj.art-019fae0d1af546d89af972101db6fd6c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T16:07:01Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-019fae0d1af546d89af972101db6fd6c2024-01-08T04:44:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13290251329025Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancyPaweł Pietruski0Katarzyna Kosińska-Kaczyńska1Agnieszka Osińska2Magdalena Zgliczyńska3Kinga Żebrowska4Katarzyna Popko5Anna Stelmaszczyk-Emmel6Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, PolandDepartment of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, PolandDepartment of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, PolandDepartment of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, PolandIntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity. It may be related to differences in plasma renin-angiotensin-aldosterone components between monochorionic and dichorionic twin pregnancies. The study aimed to analyze the plasma ANG II and ANG 1-7 concentrations in women with monochorionic and dichorionic twin gestation.MethodsA prospective observational study included 79 women between 32 and 34 weeks of gestation with twin pregnancy (31 with monochorionic gestation and 48 with dichorionic gestation). Angiotensin II and angiotensin 1-7 concentrations were measured in the collected blood samples.ResultsNo significant differences were observed in angiotensin II concentrations between the dichorionic and monochorionic group with significantly higher levels of angiotensin 1-7 being observed in the dichorionic group. Angiotensin 1-7 level was higher than angiotensin II in 20 women (64.5%) in the monochorionic group and in 42 women (87.5%, p=0.01) in the dichorionic group. Higher plasma concentrations of angiotensin II and lower concentrations of angiotensin 1-7 were found in 5 women with gestational hypertension and in 3 with preeclampsia compared to normotensive women.DiscussionIt is the first study investigating angiotensin II and angiotensin 1-7 in twin pregnancies regarding chorionicity. Our results showed that plasma angiotensin 1-7 concentration was related to chorionicity, while plasma angiotensin II level was not. In most women with twin gestation angiotensin 1-7 concentration exceeded the concentration of angiotensin II. A switch in the relation between angiotensin II and angiotensin 1-7 was observed in hypertensive pregnant women.https://www.frontiersin.org/articles/10.3389/fendo.2023.1329025/fullangiotensin IIangiotensin 1-7twin pregnancymonochorionicdichorionic |
| spellingShingle | Paweł Pietruski Katarzyna Kosińska-Kaczyńska Agnieszka Osińska Magdalena Zgliczyńska Kinga Żebrowska Katarzyna Popko Anna Stelmaszczyk-Emmel Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy Frontiers in Endocrinology angiotensin II angiotensin 1-7 twin pregnancy monochorionic dichorionic |
| title | Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| title_full | Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| title_fullStr | Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| title_full_unstemmed | Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| title_short | Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| title_sort | maternal plasma angiotensin 1 7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy |
| topic | angiotensin II angiotensin 1-7 twin pregnancy monochorionic dichorionic |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1329025/full |
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