Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru
BackgroundEpendymomas are central nervous system tumors that significantly impact the quality of life and carry a high mortality rate. Both the disease itself and its treatment cause significant morbidity. At a national level in Peru, there are no reports on clinical characteristics of the disease.M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1331790/full |
| _version_ | 1797353505481031680 |
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| author | Eduardo Perez-Roca Tatiana Negreiros Sandro Casavilca-Zambrano Luis Ojeda-Medina Rosdali Díaz-Coronado Rosdali Díaz-Coronado |
| author_facet | Eduardo Perez-Roca Tatiana Negreiros Sandro Casavilca-Zambrano Luis Ojeda-Medina Rosdali Díaz-Coronado Rosdali Díaz-Coronado |
| author_sort | Eduardo Perez-Roca |
| collection | DOAJ |
| description | BackgroundEpendymomas are central nervous system tumors that significantly impact the quality of life and carry a high mortality rate. Both the disease itself and its treatment cause significant morbidity. At a national level in Peru, there are no reports on clinical characteristics of the disease.MethodsThis retrospective study captured patient aged less than 19 years with a diagnosis of ependymoma from 2012 to 2022 at a tertiary center in Lima.Results85 patients were included with a median follow-up time was 51.6 months. The 5-year overall survival and progression-free survival were 55.89% (95% CI: 44.28 – 65.99) and 37.71% (95% CI: 26,21-49,16) respectively. The main prognostic factors identified were completed treatment (p=0.019), adjuvant chemotherapy (p=0.048), presence of metastasis (p=0.012), and disease recurrence (p=0.02).ConclusionsThe survival of patients with ependymoma is below that reported in high-income countries. Incomplete treatment and treatment abandonment are factors that negatively impact the prognosis. Further studies are needed to identify barriers in the referral and treatment process for patients with ependymoma. |
| first_indexed | 2024-03-08T13:32:03Z |
| format | Article |
| id | doaj.art-01a030124025406682863bfef78c4e5f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T13:32:03Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-01a030124025406682863bfef78c4e5f2024-01-17T07:44:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13317901331790Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in PeruEduardo Perez-Roca0Tatiana Negreiros1Sandro Casavilca-Zambrano2Luis Ojeda-Medina3Rosdali Díaz-Coronado4Rosdali Díaz-Coronado5School of Medicine, Universidad Peruana Cayetano Heredia, Lima, PeruRadiotherapy Department, Instituto Nacional de Enfermedades Neoplásicas, Lima, PeruPathology Department, Instituto Nacional de Enfermedades Neoplásicas, Lima, PeruNeurosurgery Department, Instituto Nacional de Enfermedades Neoplásicas, Lima, PeruSchool of Medicine, Universidad Peruana Cayetano Heredia, Lima, PeruPediatric Oncology Department, Instituto Nacional de Enfermedades Neoplásicas, Lima, PeruBackgroundEpendymomas are central nervous system tumors that significantly impact the quality of life and carry a high mortality rate. Both the disease itself and its treatment cause significant morbidity. At a national level in Peru, there are no reports on clinical characteristics of the disease.MethodsThis retrospective study captured patient aged less than 19 years with a diagnosis of ependymoma from 2012 to 2022 at a tertiary center in Lima.Results85 patients were included with a median follow-up time was 51.6 months. The 5-year overall survival and progression-free survival were 55.89% (95% CI: 44.28 – 65.99) and 37.71% (95% CI: 26,21-49,16) respectively. The main prognostic factors identified were completed treatment (p=0.019), adjuvant chemotherapy (p=0.048), presence of metastasis (p=0.012), and disease recurrence (p=0.02).ConclusionsThe survival of patients with ependymoma is below that reported in high-income countries. Incomplete treatment and treatment abandonment are factors that negatively impact the prognosis. Further studies are needed to identify barriers in the referral and treatment process for patients with ependymoma.https://www.frontiersin.org/articles/10.3389/fonc.2023.1331790/fullpediatricependymomatreatmentprognosisoutcomesPeru |
| spellingShingle | Eduardo Perez-Roca Tatiana Negreiros Sandro Casavilca-Zambrano Luis Ojeda-Medina Rosdali Díaz-Coronado Rosdali Díaz-Coronado Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru Frontiers in Oncology pediatric ependymoma treatment prognosis outcomes Peru |
| title | Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru |
| title_full | Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru |
| title_fullStr | Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru |
| title_full_unstemmed | Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru |
| title_short | Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru |
| title_sort | prognostic factors of pediatric ependymomas at a national cancer reference center in peru |
| topic | pediatric ependymoma treatment prognosis outcomes Peru |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1331790/full |
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