Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens

Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-...

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Main Authors: Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Nadya Luthfah, Soedarsono Soedarsono, Winariani Koesoemoprodjo, Aryani Prawita Sari
Format: Article
Language:English
Published: Interna Publishing 2022-01-01
Series:Acta Medica Indonesiana
Subjects:
Online Access:https://www.actamedindones.org/index.php/ijim/article/view/1913
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author Tutik Kusmiati
Ni Made Mertaniasih
Johanes Nugroho Eko Putranto
Budi Suprapti
Nadya Luthfah
Soedarsono Soedarsono
Winariani Koesoemoprodjo
Aryani Prawita Sari
author_facet Tutik Kusmiati
Ni Made Mertaniasih
Johanes Nugroho Eko Putranto
Budi Suprapti
Nadya Luthfah
Soedarsono Soedarsono
Winariani Koesoemoprodjo
Aryani Prawita Sari
author_sort Tutik Kusmiati
collection DOAJ
description Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of <0.001, 0.040, and <0.001, respectively. TNF-α and IL-6 between RR-TB patients on intensive phase and continuation phase showed no significant difference with p=0.530 and 0.477, respectively. CRP, TNF-α, IL-1 β, and IL-6 did not correlate with QTc interval in intensive phase (p=0.226, 0.281, 0.509, and 0.886, respectively), and also in continuation phase (0.805, 0.865, 0.406, 0.586, respectively). At 2 hours after taking the 48th-dose, moxifloxacin concentration did not correlate with QTc interval, both in intensive phase (p=0.576) and in continuation phase (p=0.691). At 1 hour before taking the 72nd-hour dose, moxifloxacin concentration also did not correlate with QTc interval in intensive phase (p=0.531) and continuation phase (p=0.209). Conclusion: Moxifloxacin concentration, CRP, and inflammatory cytokines did not correlate with QTc interval in RR-TB patients treated with shorter regimens. The use of moxifloxacin is safe but should be routinely monitored and considered the presence of other risk factors for QTc prolongation in RR-TB patients who received shorter regimens.
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spelling doaj.art-01a11b87365a411db2e869aeb54750512022-12-21T21:59:19ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-01-01541484Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter RegimensTutik Kusmiati0Ni Made Mertaniasih1Johanes Nugroho Eko Putranto2Budi Suprapti3Nadya Luthfah4Soedarsono Soedarsono5Winariani Koesoemoprodjo6Aryani Prawita Sari71. Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 2. Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Microbiology, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Clinical Pharmacy, Faculty of Pharmacy Universitas Airlangga, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, IndonesiaBackground: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of <0.001, 0.040, and <0.001, respectively. TNF-α and IL-6 between RR-TB patients on intensive phase and continuation phase showed no significant difference with p=0.530 and 0.477, respectively. CRP, TNF-α, IL-1 β, and IL-6 did not correlate with QTc interval in intensive phase (p=0.226, 0.281, 0.509, and 0.886, respectively), and also in continuation phase (0.805, 0.865, 0.406, 0.586, respectively). At 2 hours after taking the 48th-dose, moxifloxacin concentration did not correlate with QTc interval, both in intensive phase (p=0.576) and in continuation phase (p=0.691). At 1 hour before taking the 72nd-hour dose, moxifloxacin concentration also did not correlate with QTc interval in intensive phase (p=0.531) and continuation phase (p=0.209). Conclusion: Moxifloxacin concentration, CRP, and inflammatory cytokines did not correlate with QTc interval in RR-TB patients treated with shorter regimens. The use of moxifloxacin is safe but should be routinely monitored and considered the presence of other risk factors for QTc prolongation in RR-TB patients who received shorter regimens.https://www.actamedindones.org/index.php/ijim/article/view/1913pulmonologytropical diseaseinfection
spellingShingle Tutik Kusmiati
Ni Made Mertaniasih
Johanes Nugroho Eko Putranto
Budi Suprapti
Nadya Luthfah
Soedarsono Soedarsono
Winariani Koesoemoprodjo
Aryani Prawita Sari
Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
Acta Medica Indonesiana
pulmonology
tropical disease
infection
title Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
title_full Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
title_fullStr Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
title_full_unstemmed Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
title_short Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
title_sort correlation of moxifloxacin concentration c reactive protein and inflammatory cytokines on qtc interval in rifampicin resistant tuberculosis patients treated with shorter regimens
topic pulmonology
tropical disease
infection
url https://www.actamedindones.org/index.php/ijim/article/view/1913
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