Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality
Abstract Background Complications and diagnostic efficiency for liver biopsy are main concerns for clinicians. This study aimed to assess the safety and efficacy of transjugular liver biopsy (TJLB) compared with percutaneous liver biopsy (PLB) when patients had equal level of liver function and numb...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02917-x |
| _version_ | 1797452415970050048 |
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| author | Miao-Yang Chen An-Yin Yang Yi-Fan Hu Yong-Feng Yang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu |
| author_facet | Miao-Yang Chen An-Yin Yang Yi-Fan Hu Yong-Feng Yang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu |
| author_sort | Miao-Yang Chen |
| collection | DOAJ |
| description | Abstract Background Complications and diagnostic efficiency for liver biopsy are main concerns for clinicians. This study aimed to assess the safety and efficacy of transjugular liver biopsy (TJLB) compared with percutaneous liver biopsy (PLB) when patients had equal level of liver function and number of passes, using propensity score matching (PSM). Methods The clinical and pathological data of patients who received TJLB or PLB between January 2012 and October 2022 were collected. Matching factors included age, gender, cirrhosis, portal hypertension, liver function, creatinine, number of passes, hemodialysis, history of anti-coagulation and anti-platelet, and comorbidities. Coagulation indexes were not considered as matching factors due to different indications of the two techniques. Results 2711 PLBs and 30 TJLBs were evaluated. By PSM, 75 patients (50 PLBs, 25 TJLBs) were matched. The complication rates for TJLB and PLB were 4.0% (1/25) and 10.0% (5/50) (P > 0.05). Two PLBs had hepatic hemorrhage, one of which required only close monitoring (Grade 1) and the other needed hemostasis and rehydration therapy (Grade 2). The other 3 cases presented with mild abdominal pain (Grade 1). And only one TJLB presented with mild pain. The median number of complete portal tracts were 6.0 and 10.0 for TJLBs and PLBs (P < 0.05). Moreover, the median length of sample for TJLBs and PLBs were 10.0 and 16.5 mm (P < 0.05). The diagnostic efficiency of hepatopathy of unknown etiology of TJLB versus PLB groups before and after matching were 96.4% vs. 94.1% and 95.7% vs. 93.2%, respectively (P > 0.05). Conclusion TJLB is an effective invasive diagnostic procedure that expands indications for liver biopsy with reliable diagnostic quality. |
| first_indexed | 2024-03-09T15:08:26Z |
| format | Article |
| id | doaj.art-01a57cd8920948daa4afbc9e958c1868 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-09T15:08:26Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-01a57cd8920948daa4afbc9e958c18682023-11-26T13:30:05ZengBMCBMC Gastroenterology1471-230X2023-08-012311810.1186/s12876-023-02917-xTransjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic qualityMiao-Yang Chen0An-Yin Yang1Yi-Fan Hu2Yong-Feng Yang3Qing-Fang Xiong4Yan-Dan Zhong5Du-Xian Liu6Department of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineDepartment of pathology, The Second Hospital of Nanjing, Nanjing University of Chinese MedicineAbstract Background Complications and diagnostic efficiency for liver biopsy are main concerns for clinicians. This study aimed to assess the safety and efficacy of transjugular liver biopsy (TJLB) compared with percutaneous liver biopsy (PLB) when patients had equal level of liver function and number of passes, using propensity score matching (PSM). Methods The clinical and pathological data of patients who received TJLB or PLB between January 2012 and October 2022 were collected. Matching factors included age, gender, cirrhosis, portal hypertension, liver function, creatinine, number of passes, hemodialysis, history of anti-coagulation and anti-platelet, and comorbidities. Coagulation indexes were not considered as matching factors due to different indications of the two techniques. Results 2711 PLBs and 30 TJLBs were evaluated. By PSM, 75 patients (50 PLBs, 25 TJLBs) were matched. The complication rates for TJLB and PLB were 4.0% (1/25) and 10.0% (5/50) (P > 0.05). Two PLBs had hepatic hemorrhage, one of which required only close monitoring (Grade 1) and the other needed hemostasis and rehydration therapy (Grade 2). The other 3 cases presented with mild abdominal pain (Grade 1). And only one TJLB presented with mild pain. The median number of complete portal tracts were 6.0 and 10.0 for TJLBs and PLBs (P < 0.05). Moreover, the median length of sample for TJLBs and PLBs were 10.0 and 16.5 mm (P < 0.05). The diagnostic efficiency of hepatopathy of unknown etiology of TJLB versus PLB groups before and after matching were 96.4% vs. 94.1% and 95.7% vs. 93.2%, respectively (P > 0.05). Conclusion TJLB is an effective invasive diagnostic procedure that expands indications for liver biopsy with reliable diagnostic quality.https://doi.org/10.1186/s12876-023-02917-xTransjugular liver biopsyComplicationDiagnostic efficiencyPropensity score matching |
| spellingShingle | Miao-Yang Chen An-Yin Yang Yi-Fan Hu Yong-Feng Yang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality BMC Gastroenterology Transjugular liver biopsy Complication Diagnostic efficiency Propensity score matching |
| title | Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality |
| title_full | Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality |
| title_fullStr | Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality |
| title_full_unstemmed | Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality |
| title_short | Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality |
| title_sort | transjugular liver biopsy enlarge the indications for liver biopsy with reliable diagnostic quality |
| topic | Transjugular liver biopsy Complication Diagnostic efficiency Propensity score matching |
| url | https://doi.org/10.1186/s12876-023-02917-x |
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