Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers
Abstract Occupational exposure to extreme high temperatures and the increasing global temperatures necessitates a deeper understanding of the impact of heat exposure on human health. However, the molecular mechanisms underlying the response of monocytes and neutrophils to heat exposure in occupation...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15946 |
| _version_ | 1797306774402891776 |
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| author | Jirui Wen Ling Wang Juan Cheng Tengfei Ma Qiao Wen Can Li Yuhao Zou Xuehong Wan Jiang Wu Jifeng Liu |
| author_facet | Jirui Wen Ling Wang Juan Cheng Tengfei Ma Qiao Wen Can Li Yuhao Zou Xuehong Wan Jiang Wu Jifeng Liu |
| author_sort | Jirui Wen |
| collection | DOAJ |
| description | Abstract Occupational exposure to extreme high temperatures and the increasing global temperatures necessitates a deeper understanding of the impact of heat exposure on human health. However, the molecular mechanisms underlying the response of monocytes and neutrophils to heat exposure in occupational population remain to be fully elucidated. This study used longitudinal transcriptome to assess the impact of acute heat exposure (50°C for 30 min) in 10 subjects from a mine rescue team before acute heat exposure (baseline) and at 5 min, 30 min, 1 h, and 24 h after acute heat exposure (recovery). The time‐series analysis revealed a coordinated molecular choreography of changes involving inflammation, coagulation, extracellular matrix, and energy metabolism. Importantly, the study characterized the inflammatory signature associated with heat exposure in monocytes and neutrophils, as evidenced by the rapid activation of the inflammation‐related transcriptome following heat exposure. Additionally, we pinpointed potential regulators, such as NR4A1, FOSL1, EGR3, and ATF3. In summary, the study suggested that the initial response to heat stress in monocytes and neutrophils from mine rescue team member was primarily characterized by a pro‐inflammatory stress response, which could potentially lead to the development of inflammation and ultimately result in a systemic inflammatory response in heatstroke. |
| first_indexed | 2024-03-08T00:46:40Z |
| format | Article |
| id | doaj.art-01a81bf42ca44f63ba9f3b637b142844 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T00:46:40Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-01a81bf42ca44f63ba9f3b637b1428442024-02-15T06:28:36ZengWileyPhysiological Reports2051-817X2024-02-01123n/an/a10.14814/phy2.15946Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuersJirui Wen0Ling Wang1Juan Cheng2Tengfei Ma3Qiao Wen4Can Li5Yuhao Zou6Xuehong Wan7Jiang Wu8Jifeng Liu9Department of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaDepartment of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital Sichuan University Chengdu ChinaAbstract Occupational exposure to extreme high temperatures and the increasing global temperatures necessitates a deeper understanding of the impact of heat exposure on human health. However, the molecular mechanisms underlying the response of monocytes and neutrophils to heat exposure in occupational population remain to be fully elucidated. This study used longitudinal transcriptome to assess the impact of acute heat exposure (50°C for 30 min) in 10 subjects from a mine rescue team before acute heat exposure (baseline) and at 5 min, 30 min, 1 h, and 24 h after acute heat exposure (recovery). The time‐series analysis revealed a coordinated molecular choreography of changes involving inflammation, coagulation, extracellular matrix, and energy metabolism. Importantly, the study characterized the inflammatory signature associated with heat exposure in monocytes and neutrophils, as evidenced by the rapid activation of the inflammation‐related transcriptome following heat exposure. Additionally, we pinpointed potential regulators, such as NR4A1, FOSL1, EGR3, and ATF3. In summary, the study suggested that the initial response to heat stress in monocytes and neutrophils from mine rescue team member was primarily characterized by a pro‐inflammatory stress response, which could potentially lead to the development of inflammation and ultimately result in a systemic inflammatory response in heatstroke.https://doi.org/10.14814/phy2.15946acute heat exposuremonocytesneutrophilstranscriptome |
| spellingShingle | Jirui Wen Ling Wang Juan Cheng Tengfei Ma Qiao Wen Can Li Yuhao Zou Xuehong Wan Jiang Wu Jifeng Liu Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers Physiological Reports acute heat exposure monocytes neutrophils transcriptome |
| title | Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| title_full | Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| title_fullStr | Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| title_full_unstemmed | Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| title_short | Time‐series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| title_sort | time series transcriptome reveals inflammatory signature in monocytes and neutrophils following acute heat exposure in mine rescuers |
| topic | acute heat exposure monocytes neutrophils transcriptome |
| url | https://doi.org/10.14814/phy2.15946 |
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