Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders
Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currentl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/2/216 |
| _version_ | 1797618787986440192 |
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| author | Olaia Martínez-Iglesias Vinogran Naidoo Iván Carrera Lola Corzo Ramón Cacabelos |
| author_facet | Olaia Martínez-Iglesias Vinogran Naidoo Iván Carrera Lola Corzo Ramón Cacabelos |
| author_sort | Olaia Martínez-Iglesias |
| collection | DOAJ |
| description | Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts on neurodegeneration. |
| first_indexed | 2024-03-11T08:17:31Z |
| format | Article |
| id | doaj.art-01aa3e6b755345bcaaab9a9048fd89c8 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:17:31Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-01aa3e6b755345bcaaab9a9048fd89c82023-11-16T22:36:36ZengMDPI AGPharmaceuticals1424-82472023-01-0116221610.3390/ph16020216Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative DisordersOlaia Martínez-Iglesias0Vinogran Naidoo1Iván Carrera2Lola Corzo3Ramón Cacabelos4EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, SpainEuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, SpainEuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, SpainEuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, SpainEuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, SpainNeurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts on neurodegeneration.https://www.mdpi.com/1424-8247/16/2/216epigeneticsneurodegenerationepinutraceuticalsDNA methylationhistone modificationsmiRNAs |
| spellingShingle | Olaia Martínez-Iglesias Vinogran Naidoo Iván Carrera Lola Corzo Ramón Cacabelos Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders Pharmaceuticals epigenetics neurodegeneration epinutraceuticals DNA methylation histone modifications miRNAs |
| title | Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders |
| title_full | Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders |
| title_fullStr | Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders |
| title_full_unstemmed | Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders |
| title_short | Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders |
| title_sort | natural bioactive products as epigenetic modulators for treating neurodegenerative disorders |
| topic | epigenetics neurodegeneration epinutraceuticals DNA methylation histone modifications miRNAs |
| url | https://www.mdpi.com/1424-8247/16/2/216 |
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