Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial
Background and objectives: Ajuga genus is used as wound healing in traditional Persian medicine. This study aimed to evaluate the effectiveness of Ajuga chamaecistus ssp. tomentella ointment on healing pressure ulcers in patients admitted to the intensive care unit. Methods: In this randomized, doub...
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Iranian Society of Pharmacognosy
2024-04-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | https://www.rjpharmacognosy.ir/article_191755_46861301e1a2ea430c39c9722c1dea12.pdf |
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| author | Mohsen Adib Mohammad Hossein Jarrahzadeh Tayebeh Toliyat Laila Shirbeigi Nafiseh Khosravi Dehaghi Seyede Nargess Sadati Lamardi* |
| author_facet | Mohsen Adib Mohammad Hossein Jarrahzadeh Tayebeh Toliyat Laila Shirbeigi Nafiseh Khosravi Dehaghi Seyede Nargess Sadati Lamardi* |
| author_sort | Mohsen Adib |
| collection | DOAJ |
| description | Background and objectives: Ajuga genus is used as wound healing in traditional Persian medicine. This study aimed to evaluate the effectiveness of Ajuga chamaecistus ssp. tomentella ointment on healing pressure ulcers in patients admitted to the intensive care unit. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 131 patients with grade 1 or 2 pressure ulcers were randomly assigned into one of two groups through simple randomization. The study group received 3% Ajuga ointment, containing 17.26 µg/mL of 20-hydroxyecdysone (ecdysterone) as the main compound, while the control group received placebo twice a day for 14 days in addition to the standard care for pressure ulcers Changes in the degree and size of wounds were considered as the primary outcomes of the study based on the 2-digit Stirling scale. Results: Forty patients in each group completed the research. Mean (95% confidence interval) difference values, for wound degree, between two groups on day 7 vs. day 0 was -0.88 (-1.01 to -0.76, p<0.001), and on day 14 vs. day 0 was -1.57 (-1.78 to -1.36, p<0.001). Mean (95% confidence interval) difference values, for wound area, between two groups on day 7 vs. day 0 was -1.730(-1.979 to -1.48, p<0.001), and on day 14 vs. day 0 was -3.142(-3.563 to -2.72, p<0.001).Conclusion: Topical application of Ajuga ointment significantly improved pressure ulcers on days 7 and 14 compared to placebo. Evaluation of the effects of this plant on a larger sample size, for a longer period of time and in different medical centers is recommended. |
| first_indexed | 2024-04-24T08:53:54Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-04-24T08:53:54Z |
| publishDate | 2024-04-01 |
| publisher | Iranian Society of Pharmacognosy |
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| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-01aa6f76c35e4bc6a23479c377458efc2024-04-16T08:34:22ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772024-04-01112475910.22127/rjp.2024.430500.2303191755Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical TrialMohsen Adib0Mohammad Hossein Jarrahzadeh1Tayebeh Toliyat2Laila Shirbeigi3Nafiseh Khosravi Dehaghi4Seyede Nargess Sadati Lamardi*5Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Anesthesia and Intensive Care Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran.Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Background and objectives: Ajuga genus is used as wound healing in traditional Persian medicine. This study aimed to evaluate the effectiveness of Ajuga chamaecistus ssp. tomentella ointment on healing pressure ulcers in patients admitted to the intensive care unit. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 131 patients with grade 1 or 2 pressure ulcers were randomly assigned into one of two groups through simple randomization. The study group received 3% Ajuga ointment, containing 17.26 µg/mL of 20-hydroxyecdysone (ecdysterone) as the main compound, while the control group received placebo twice a day for 14 days in addition to the standard care for pressure ulcers Changes in the degree and size of wounds were considered as the primary outcomes of the study based on the 2-digit Stirling scale. Results: Forty patients in each group completed the research. Mean (95% confidence interval) difference values, for wound degree, between two groups on day 7 vs. day 0 was -0.88 (-1.01 to -0.76, p<0.001), and on day 14 vs. day 0 was -1.57 (-1.78 to -1.36, p<0.001). Mean (95% confidence interval) difference values, for wound area, between two groups on day 7 vs. day 0 was -1.730(-1.979 to -1.48, p<0.001), and on day 14 vs. day 0 was -3.142(-3.563 to -2.72, p<0.001).Conclusion: Topical application of Ajuga ointment significantly improved pressure ulcers on days 7 and 14 compared to placebo. Evaluation of the effects of this plant on a larger sample size, for a longer period of time and in different medical centers is recommended.https://www.rjpharmacognosy.ir/article_191755_46861301e1a2ea430c39c9722c1dea12.pdfajugaecdysteronepersian medicinepressure ulcerrandomized controlled trial |
| spellingShingle | Mohsen Adib Mohammad Hossein Jarrahzadeh Tayebeh Toliyat Laila Shirbeigi Nafiseh Khosravi Dehaghi Seyede Nargess Sadati Lamardi* Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial Research Journal of Pharmacognosy ajuga ecdysterone persian medicine pressure ulcer randomized controlled trial |
| title | Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_full | Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_fullStr | Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_short | Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_sort | wound healing effect of a topical product from ajuga chamaecistus ssp tomentella in pressure ulcer a randomized double blind placebo controlled clinical trial |
| topic | ajuga ecdysterone persian medicine pressure ulcer randomized controlled trial |
| url | https://www.rjpharmacognosy.ir/article_191755_46861301e1a2ea430c39c9722c1dea12.pdf |
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