The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems
The skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both commensal and pathogenic, which encompass bacteria, viruses, fungi, and parasites. The skin and intestine must maintain homeostasis with the div...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02950/full |
| _version_ | 1811333984759578624 |
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| author | Margaret Coates Min Jin Lee Diana Norton Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod |
| author_facet | Margaret Coates Min Jin Lee Diana Norton Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod |
| author_sort | Margaret Coates |
| collection | DOAJ |
| description | The skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both commensal and pathogenic, which encompass bacteria, viruses, fungi, and parasites. The skin and intestine must maintain homeostasis with the diversity of commensal organisms present on epithelial surfaces. Here we review the current literature pertaining to epithelial barrier formation, microbial composition, and the complex regulatory mechanisms governing the interaction between the innate immune system and microbiota in the skin and intestine. We also compare and contrast the skin and intestine—two different organ systems responsible creating a protective barrier against the external environment, each of which has unique mechanisms for interaction with commensal populations and host repair. |
| first_indexed | 2024-04-13T17:01:02Z |
| format | Article |
| id | doaj.art-01ad0cf8e4524f0a9fb4dfe365a87ff3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:01:02Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-01ad0cf8e4524f0a9fb4dfe365a87ff32022-12-22T02:38:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02950496479The Skin and Intestinal Microbiota and Their Specific Innate Immune SystemsMargaret Coates0Min Jin Lee1Diana Norton2Amanda S. MacLeod3Amanda S. MacLeod4Amanda S. MacLeod5Amanda S. MacLeod6Department of Dermatology, Duke University, Durham, NC, United StatesDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, United StatesDepartment of Dermatology, Duke University, Durham, NC, United StatesDepartment of Dermatology, Duke University, Durham, NC, United StatesDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, United StatesDepartment of Immunology, Duke University, Durham, NC, United StatesPinnell Center for Investigative Dermatology, Duke University, Durham, NC, United StatesThe skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both commensal and pathogenic, which encompass bacteria, viruses, fungi, and parasites. The skin and intestine must maintain homeostasis with the diversity of commensal organisms present on epithelial surfaces. Here we review the current literature pertaining to epithelial barrier formation, microbial composition, and the complex regulatory mechanisms governing the interaction between the innate immune system and microbiota in the skin and intestine. We also compare and contrast the skin and intestine—two different organ systems responsible creating a protective barrier against the external environment, each of which has unique mechanisms for interaction with commensal populations and host repair.https://www.frontiersin.org/article/10.3389/fimmu.2019.02950/fullskinintestinemicrobiomeinnate immunityAMPs |
| spellingShingle | Margaret Coates Min Jin Lee Diana Norton Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod Amanda S. MacLeod The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems Frontiers in Immunology skin intestine microbiome innate immunity AMPs |
| title | The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems |
| title_full | The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems |
| title_fullStr | The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems |
| title_full_unstemmed | The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems |
| title_short | The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems |
| title_sort | skin and intestinal microbiota and their specific innate immune systems |
| topic | skin intestine microbiome innate immunity AMPs |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02950/full |
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