P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.

P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.

The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. Also PRODH2, which degrades 4-hydroxy-L-proline, a product of protein (e.g. collagen) cata...

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Bibliographic Details
Main Authors: Ivan Raimondi, Yari Ciribilli, Paola Monti, Alessandra Bisio, Loredano Pollegioni, Gilberto Fronza, Alberto Inga, Paola Campomenosi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3704516?pdf=render

Internet

http://europepmc.org/articles/PMC3704516?pdf=render

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