Contribution of atrial myofiber architecture to atrial fibrillation
<h4>Background</h4> The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. <h4>Methods</h4> Transg...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888724/?tool=EBI |
| _version_ | 1811173511813660672 |
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| author | Roya Kamali Eugene Kwan Misha Regouski T. Jared Bunch Derek J. Dosdall Ed Hsu Rob S. Macleod Irina Polejaeva Ravi Ranjan |
| author_facet | Roya Kamali Eugene Kwan Misha Regouski T. Jared Bunch Derek J. Dosdall Ed Hsu Rob S. Macleod Irina Polejaeva Ravi Ranjan |
| author_sort | Roya Kamali |
| collection | DOAJ |
| description | <h4>Background</h4> The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. <h4>Methods</h4> Transgenic goats with cardiac-specific overexpression of constitutively active TGF-β1 (n = 14) underwent AF inducibility testing by rapid pacing in the left atrium. We chose a minimum of 10 minutes of sustained AF as a cut-off for AF inducibility. Explanted hearts underwent DTI to determine the fiber direction. Using tractography data, we clustered, visualized, and quantified the fiber helix angles in 8 different regions of the left atrial wall using two reference vectors defined based on anatomical landmarks. <h4>Results</h4> Sustained AF was induced in 7 out of 14 goats. The mean helix fiber angles in 7 out of 8 selected regions were statistically different (P-Value < 0.05) in the AF inducible group. The average fractional anisotropy (FA) and the mean diffusivity (MD) were similar in the two groups with FA of 0.32±0.08 and MD of 8.54±1.72 mm2/s in the non-inducible group and FA of 0.31±0.05 (P-value = 0.90) and MD of 8.68±1.60 mm2/s (P-value = 0.88) in the inducible group. <h4>Conclusions</h4> DTI based fiber direction shows significant variability across subjects with a significant difference between animals that are AF inducible versus animals that are not inducible. Fiber direction might be contributing to the initiation and sustaining of AF, and its role needs to be investigated further. |
| first_indexed | 2024-04-10T17:48:12Z |
| format | Article |
| id | doaj.art-01af2139d346446a9e69e35400904780 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T17:48:12Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-01af2139d346446a9e69e354009047802023-02-02T22:58:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Contribution of atrial myofiber architecture to atrial fibrillationRoya KamaliEugene KwanMisha RegouskiT. Jared BunchDerek J. DosdallEd HsuRob S. MacleodIrina PolejaevaRavi Ranjan<h4>Background</h4> The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber direction derived from Diffusion Tensor Imaging (DTI) with AF inducibility. <h4>Methods</h4> Transgenic goats with cardiac-specific overexpression of constitutively active TGF-β1 (n = 14) underwent AF inducibility testing by rapid pacing in the left atrium. We chose a minimum of 10 minutes of sustained AF as a cut-off for AF inducibility. Explanted hearts underwent DTI to determine the fiber direction. Using tractography data, we clustered, visualized, and quantified the fiber helix angles in 8 different regions of the left atrial wall using two reference vectors defined based on anatomical landmarks. <h4>Results</h4> Sustained AF was induced in 7 out of 14 goats. The mean helix fiber angles in 7 out of 8 selected regions were statistically different (P-Value < 0.05) in the AF inducible group. The average fractional anisotropy (FA) and the mean diffusivity (MD) were similar in the two groups with FA of 0.32±0.08 and MD of 8.54±1.72 mm2/s in the non-inducible group and FA of 0.31±0.05 (P-value = 0.90) and MD of 8.68±1.60 mm2/s (P-value = 0.88) in the inducible group. <h4>Conclusions</h4> DTI based fiber direction shows significant variability across subjects with a significant difference between animals that are AF inducible versus animals that are not inducible. Fiber direction might be contributing to the initiation and sustaining of AF, and its role needs to be investigated further.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888724/?tool=EBI |
| spellingShingle | Roya Kamali Eugene Kwan Misha Regouski T. Jared Bunch Derek J. Dosdall Ed Hsu Rob S. Macleod Irina Polejaeva Ravi Ranjan Contribution of atrial myofiber architecture to atrial fibrillation PLoS ONE |
| title | Contribution of atrial myofiber architecture to atrial fibrillation |
| title_full | Contribution of atrial myofiber architecture to atrial fibrillation |
| title_fullStr | Contribution of atrial myofiber architecture to atrial fibrillation |
| title_full_unstemmed | Contribution of atrial myofiber architecture to atrial fibrillation |
| title_short | Contribution of atrial myofiber architecture to atrial fibrillation |
| title_sort | contribution of atrial myofiber architecture to atrial fibrillation |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888724/?tool=EBI |
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