Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature

Temporary elevation of tumor temperature, also known as hyperthermia, is a safe and well-tolerated treatment modality. The efficacy of hyperthermia can be improved by efficient thermosensitizers, and various candidate drugs, including inhibitors of the heat stress response, have been explored in vit...

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Bibliographic Details
Main Authors: Enzo M. Scutigliani, Jons van Hattum, Fernando Lobo-Cerna, Joanne Kruyswijk, Maja Myrcha, Frederique E. G. A. Dekkers, Ron A. Hoebe, Finn Edwards, Jetta J. Oppelaar, Liffert Vogt, Sanne Bootsma, Maarten F. Bijlsma, Daisy I. Picavet, Johannes Crezee, Jorg R. Oddens, Theo M. de Reijke, Przemek M. Krawczyk
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
hyperthermia
heat stress
elesclomol
cancer
copper
Online Access:https://www.mdpi.com/1422-0067/25/1/423

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