Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction
Mixed lipid micelles were proposed to facilitate life through their documented growth dynamics and catalytic properties. Our previous research predicted that micellar self-reproduction involves catalyzed accretion of lipid molecules by the residing lipids, leading to compositional homeostasis. Here,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/955 |
| _version_ | 1797433364208156672 |
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| author | Amit Kahana Doron Lancet Zoltan Palmai |
| author_facet | Amit Kahana Doron Lancet Zoltan Palmai |
| author_sort | Amit Kahana |
| collection | DOAJ |
| description | Mixed lipid micelles were proposed to facilitate life through their documented growth dynamics and catalytic properties. Our previous research predicted that micellar self-reproduction involves catalyzed accretion of lipid molecules by the residing lipids, leading to compositional homeostasis. Here, we employ atomistic Molecular Dynamics simulations, beginning with 54 lipid monomers, tracking an entire course of micellar accretion. This was done to examine the self-assembly of variegated lipid clusters, allowing us to measure entry and exit rates of monomeric lipids into pre-micelles with different compositions and sizes. We observe considerable rate-modifications that depend on the assembly composition and scrutinize the underlying mechanisms as well as the energy contributions. Lastly, we describe the measured potential for compositional homeostasis in our simulated mixed micelles. This affirms the basis for micellar self-reproduction, with implications for the study of the origin of life. |
| first_indexed | 2024-03-09T10:15:59Z |
| format | Article |
| id | doaj.art-01b11d1354c74ebabb5c0290c26251d9 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T10:15:59Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-01b11d1354c74ebabb5c0290c26251d92023-12-01T22:21:38ZengMDPI AGLife2075-17292022-06-0112795510.3390/life12070955Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network ReproductionAmit Kahana0Doron Lancet1Zoltan Palmai2Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, IsraelDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, IsraelDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 761001, IsraelMixed lipid micelles were proposed to facilitate life through their documented growth dynamics and catalytic properties. Our previous research predicted that micellar self-reproduction involves catalyzed accretion of lipid molecules by the residing lipids, leading to compositional homeostasis. Here, we employ atomistic Molecular Dynamics simulations, beginning with 54 lipid monomers, tracking an entire course of micellar accretion. This was done to examine the self-assembly of variegated lipid clusters, allowing us to measure entry and exit rates of monomeric lipids into pre-micelles with different compositions and sizes. We observe considerable rate-modifications that depend on the assembly composition and scrutinize the underlying mechanisms as well as the energy contributions. Lastly, we describe the measured potential for compositional homeostasis in our simulated mixed micelles. This affirms the basis for micellar self-reproduction, with implications for the study of the origin of life.https://www.mdpi.com/2075-1729/12/7/955origin of lifeMolecular Dynamics simulationmixed micellesaccretion kinetics |
| spellingShingle | Amit Kahana Doron Lancet Zoltan Palmai Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction Life origin of life Molecular Dynamics simulation mixed micelles accretion kinetics |
| title | Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction |
| title_full | Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction |
| title_fullStr | Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction |
| title_full_unstemmed | Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction |
| title_short | Micellar Composition Affects Lipid Accretion Kinetics in Molecular Dynamics Simulations: Support for Lipid Network Reproduction |
| title_sort | micellar composition affects lipid accretion kinetics in molecular dynamics simulations support for lipid network reproduction |
| topic | origin of life Molecular Dynamics simulation mixed micelles accretion kinetics |
| url | https://www.mdpi.com/2075-1729/12/7/955 |
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