Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/21/6541 |
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| author | Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju |
| author_facet | Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju |
| author_sort | Omolola R. Oyenihi |
| collection | DOAJ |
| description | Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied ‘candidate plants’ for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard. |
| first_indexed | 2024-03-10T05:55:27Z |
| format | Article |
| id | doaj.art-01b12944cb5a473fbfa054bdb1723926 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T05:55:27Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-01b12944cb5a473fbfa054bdb17239262023-11-22T21:22:51ZengMDPI AGMolecules1420-30492021-10-012621654110.3390/molecules26216541Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with MetabolomicsOmolola R. Oyenihi0Ayodeji B. Oyenihi1Joseph O. Erhabor2Motlalepula G. Matsabisa3Oluwafemi O. Oguntibeju4Oxidative Stress Research Centre, Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South AfricaFunctional Foods Research Unit, Faculty of Applied Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South AfricaDepartment of Pharmacology, University of the Free State, P.O. Box 339, Bloemfontein 9300, South AfricaDepartment of Pharmacology, University of the Free State, P.O. Box 339, Bloemfontein 9300, South AfricaOxidative Stress Research Centre, Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South AfricaMetabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied ‘candidate plants’ for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard.https://www.mdpi.com/1420-3049/26/21/6541cancerherbmetabolic reprogrammingmetabolomicsphytomedicine |
| spellingShingle | Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics Molecules cancer herb metabolic reprogramming metabolomics phytomedicine |
| title | Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics |
| title_full | Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics |
| title_fullStr | Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics |
| title_full_unstemmed | Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics |
| title_short | Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics |
| title_sort | unravelling the anticancer mechanisms of traditional herbal medicines with metabolomics |
| topic | cancer herb metabolic reprogramming metabolomics phytomedicine |
| url | https://www.mdpi.com/1420-3049/26/21/6541 |
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