Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts
Abstract The arterial occlusive disease is one of the leading causes of cardiovascular diseases, often requiring revascularization. Lack of suitable small-diameter vascular grafts (SDVGs), infection, thrombosis, and intimal hyperplasia associated with synthetic vascular grafts lead to a low success...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2023-06-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-023-00399-2 |
| _version_ | 1797280485206917120 |
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| author | Mei-Xian Li Qian-Qi Wei Hui-Lin Mo Yu Ren Wei Zhang Huan-Jun Lu Yoon Ki Joung |
| author_facet | Mei-Xian Li Qian-Qi Wei Hui-Lin Mo Yu Ren Wei Zhang Huan-Jun Lu Yoon Ki Joung |
| author_sort | Mei-Xian Li |
| collection | DOAJ |
| description | Abstract The arterial occlusive disease is one of the leading causes of cardiovascular diseases, often requiring revascularization. Lack of suitable small-diameter vascular grafts (SDVGs), infection, thrombosis, and intimal hyperplasia associated with synthetic vascular grafts lead to a low success rate of SDVGs (< 6 mm) transplantation in the clinical treatment of cardiovascular diseases. The development of fabrication technology along with vascular tissue engineering and regenerative medicine technology allows biological tissue-engineered vascular grafts to become living grafts, which can integrate, remodel, and repair the host vessels as well as respond to the surrounding mechanical and biochemical stimuli. Hence, they potentially alleviate the shortage of existing vascular grafts. This paper evaluates the current advanced fabrication technologies for SDVGs, including electrospinning, molding, 3D printing, decellularization, and so on. Various characteristics of synthetic polymers and surface modification methods are also introduced. In addition, it also provides interdisciplinary insights into the future of small-diameter prostheses and discusses vital factors and perspectives for developing such prostheses in clinical applications. We propose that the performance of SDVGs can be improved by integrating various technologies in the near future. Graphical Abstract |
| first_indexed | 2024-03-07T16:40:57Z |
| format | Article |
| id | doaj.art-01b4ee3fd1ce42ffb04c60b36c231dcb |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T16:40:57Z |
| publishDate | 2023-06-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-01b4ee3fd1ce42ffb04c60b36c231dcb2024-03-03T08:00:39ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242023-06-0127112210.1186/s40824-023-00399-2Challenges and advances in materials and fabrication technologies of small-diameter vascular graftsMei-Xian Li0Qian-Qi Wei1Hui-Lin Mo2Yu Ren3Wei Zhang4Huan-Jun Lu5Yoon Ki Joung6National and Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection, Nantong UniversityDepartment of Infectious Diseases, General Hospital of Tibet Military CommandSchool of Textile and Clothing, Nantong UniversityNational and Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection, Nantong UniversityNational and Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection, Nantong UniversityInstitute of Special Environmental Medicine, Nantong UniversityCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and TechnologyAbstract The arterial occlusive disease is one of the leading causes of cardiovascular diseases, often requiring revascularization. Lack of suitable small-diameter vascular grafts (SDVGs), infection, thrombosis, and intimal hyperplasia associated with synthetic vascular grafts lead to a low success rate of SDVGs (< 6 mm) transplantation in the clinical treatment of cardiovascular diseases. The development of fabrication technology along with vascular tissue engineering and regenerative medicine technology allows biological tissue-engineered vascular grafts to become living grafts, which can integrate, remodel, and repair the host vessels as well as respond to the surrounding mechanical and biochemical stimuli. Hence, they potentially alleviate the shortage of existing vascular grafts. This paper evaluates the current advanced fabrication technologies for SDVGs, including electrospinning, molding, 3D printing, decellularization, and so on. Various characteristics of synthetic polymers and surface modification methods are also introduced. In addition, it also provides interdisciplinary insights into the future of small-diameter prostheses and discusses vital factors and perspectives for developing such prostheses in clinical applications. We propose that the performance of SDVGs can be improved by integrating various technologies in the near future. Graphical Abstracthttps://doi.org/10.1186/s40824-023-00399-2Small-diameter vascular graftsSurface modificationCardiovascular diseasesBiomimeticsTissue engineering |
| spellingShingle | Mei-Xian Li Qian-Qi Wei Hui-Lin Mo Yu Ren Wei Zhang Huan-Jun Lu Yoon Ki Joung Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts Biomaterials Research Small-diameter vascular grafts Surface modification Cardiovascular diseases Biomimetics Tissue engineering |
| title | Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts |
| title_full | Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts |
| title_fullStr | Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts |
| title_full_unstemmed | Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts |
| title_short | Challenges and advances in materials and fabrication technologies of small-diameter vascular grafts |
| title_sort | challenges and advances in materials and fabrication technologies of small diameter vascular grafts |
| topic | Small-diameter vascular grafts Surface modification Cardiovascular diseases Biomimetics Tissue engineering |
| url | https://doi.org/10.1186/s40824-023-00399-2 |
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