Habenula as a Neural Substrate for Aggressive Behavior
Over the past decades, an ever growing body of literature has explored the anatomy, connections, and functions of the habenula (Hb). It has been postulated that the Hb plays a central role in the control of the monoaminergic system, thus influencing a wide range of behavioral responses, and particip...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.817302/full |
| _version_ | 1818297149462413312 |
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| author | Flavia Venetucci Gouveia George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim |
| author_facet | Flavia Venetucci Gouveia George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim |
| author_sort | Flavia Venetucci Gouveia |
| collection | DOAJ |
| description | Over the past decades, an ever growing body of literature has explored the anatomy, connections, and functions of the habenula (Hb). It has been postulated that the Hb plays a central role in the control of the monoaminergic system, thus influencing a wide range of behavioral responses, and participating in the pathophysiology of a number of psychiatric disorders and neuropsychiatric symptoms, such as aggressive behaviors. Aggressive behaviors are frequently accompanied by restlessness and agitation, and are commonly observed in patients with psychiatric disorders, intellectual disabilities, and neurodegenerative diseases of aging. Recently, the Hb has been explored as a new target for neuromodulation therapies, such as deep brain stimulation, with promising results. Here we review the anatomical organization of the habenula and discuss several distinct mechanisms by which the Hb is involved in the modulation of aggressive behaviors, and propose new investigations for the development of novel treatments targeting the habenula to reduce aggressive behaviors. |
| first_indexed | 2024-12-13T04:14:51Z |
| format | Article |
| id | doaj.art-01b4f86131084a70b0081129ab1417d8 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T04:14:51Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-01b4f86131084a70b0081129ab1417d82022-12-21T23:59:55ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-02-011310.3389/fpsyt.2022.817302817302Habenula as a Neural Substrate for Aggressive BehaviorFlavia Venetucci Gouveia0George M. Ibrahim1George M. Ibrahim2George M. Ibrahim3George M. Ibrahim4George M. Ibrahim5Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, CanadaNeuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, CanadaDivision of Neurosurgery, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, CanadaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, University of Toronto, Toronto, ON, CanadaOver the past decades, an ever growing body of literature has explored the anatomy, connections, and functions of the habenula (Hb). It has been postulated that the Hb plays a central role in the control of the monoaminergic system, thus influencing a wide range of behavioral responses, and participating in the pathophysiology of a number of psychiatric disorders and neuropsychiatric symptoms, such as aggressive behaviors. Aggressive behaviors are frequently accompanied by restlessness and agitation, and are commonly observed in patients with psychiatric disorders, intellectual disabilities, and neurodegenerative diseases of aging. Recently, the Hb has been explored as a new target for neuromodulation therapies, such as deep brain stimulation, with promising results. Here we review the anatomical organization of the habenula and discuss several distinct mechanisms by which the Hb is involved in the modulation of aggressive behaviors, and propose new investigations for the development of novel treatments targeting the habenula to reduce aggressive behaviors.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.817302/fullhabenulaaggressive behavior (AB)neuropsychiatric symptomspreclinical studiesreview |
| spellingShingle | Flavia Venetucci Gouveia George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim George M. Ibrahim Habenula as a Neural Substrate for Aggressive Behavior Frontiers in Psychiatry habenula aggressive behavior (AB) neuropsychiatric symptoms preclinical studies review |
| title | Habenula as a Neural Substrate for Aggressive Behavior |
| title_full | Habenula as a Neural Substrate for Aggressive Behavior |
| title_fullStr | Habenula as a Neural Substrate for Aggressive Behavior |
| title_full_unstemmed | Habenula as a Neural Substrate for Aggressive Behavior |
| title_short | Habenula as a Neural Substrate for Aggressive Behavior |
| title_sort | habenula as a neural substrate for aggressive behavior |
| topic | habenula aggressive behavior (AB) neuropsychiatric symptoms preclinical studies review |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.817302/full |
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