White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults
Microstructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), respectively. The extent to which diminished microstructure prece...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00345/full |
| _version_ | 1818286017533181952 |
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| author | Patrick J. Lao Robert S. Vorburger Robert S. Vorburger Atul Narkhede Yunglin Gazes Kay C. Igwe Juliet Colón Erica Amarante Vanessa A. Guzman Briana S. Last Christian Habeck Christian Habeck Yaakov Stern Yaakov Stern Adam M. Brickman Adam M. Brickman |
| author_facet | Patrick J. Lao Robert S. Vorburger Robert S. Vorburger Atul Narkhede Yunglin Gazes Kay C. Igwe Juliet Colón Erica Amarante Vanessa A. Guzman Briana S. Last Christian Habeck Christian Habeck Yaakov Stern Yaakov Stern Adam M. Brickman Adam M. Brickman |
| author_sort | Patrick J. Lao |
| collection | DOAJ |
| description | Microstructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), respectively. The extent to which diminished microstructure precedes or results from macrostructural white matter damage is poorly understood. This study evaluated the hypothesis that white matter areas with normatively lower microstructure in young adults are most susceptible to develop WMH in older adults. Forty-nine younger participants (age = 25.8 ± 2.8 years) underwent diffusion-weighted imaging (DWI), and 557 older participants (age = 73.9 ± 5.7 years) underwent DWI and T2-weighted magnetic resonance imaging (MRI). In older adults, WMH had a mostly periventricular distribution with higher frequency in frontal regions. We found lower FA in areas of frank WMH compared to normal-appearing white matter (NAWM) in older adults. Then, to determine if areas of normatively lower white matter microstructure spatially overlap with areas that frequently develop macrostructural damage in older age, we created a WMH frequency map in which each voxel represented the percentage of older adults with a WMH in that voxel. We found lower normative FA in young adults with regions frequently segmented as WMH in older adults. We conclude that low white matter microstructure is observed in areas of white matter macrostructural damage, but white matter microstructure is also normatively low (i.e., at ages 20–30) in regions with high WMH frequency, prior to white matter macrostructural damage. |
| first_indexed | 2024-12-13T01:17:54Z |
| format | Article |
| id | doaj.art-01b7238aeecc434f95ded5ac18b0a8f7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T01:17:54Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-01b7238aeecc434f95ded5ac18b0a8f72022-12-22T00:04:18ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-12-011110.3389/fnagi.2019.00345493150White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older AdultsPatrick J. Lao0Robert S. Vorburger1Robert S. Vorburger2Atul Narkhede3Yunglin Gazes4Kay C. Igwe5Juliet Colón6Erica Amarante7Vanessa A. Guzman8Briana S. Last9Christian Habeck10Christian Habeck11Yaakov Stern12Yaakov Stern13Adam M. Brickman14Adam M. Brickman15Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesInstitute of Applied Simulation, School of Life Sciences and Facility Management, Zurich University of Applied Sciences, Wädenswil, SwitzerlandTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesMicrostructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), respectively. The extent to which diminished microstructure precedes or results from macrostructural white matter damage is poorly understood. This study evaluated the hypothesis that white matter areas with normatively lower microstructure in young adults are most susceptible to develop WMH in older adults. Forty-nine younger participants (age = 25.8 ± 2.8 years) underwent diffusion-weighted imaging (DWI), and 557 older participants (age = 73.9 ± 5.7 years) underwent DWI and T2-weighted magnetic resonance imaging (MRI). In older adults, WMH had a mostly periventricular distribution with higher frequency in frontal regions. We found lower FA in areas of frank WMH compared to normal-appearing white matter (NAWM) in older adults. Then, to determine if areas of normatively lower white matter microstructure spatially overlap with areas that frequently develop macrostructural damage in older age, we created a WMH frequency map in which each voxel represented the percentage of older adults with a WMH in that voxel. We found lower normative FA in young adults with regions frequently segmented as WMH in older adults. We conclude that low white matter microstructure is observed in areas of white matter macrostructural damage, but white matter microstructure is also normatively low (i.e., at ages 20–30) in regions with high WMH frequency, prior to white matter macrostructural damage.https://www.frontiersin.org/article/10.3389/fnagi.2019.00345/fullwhite matter microstructurewhite matter macrostructurediffusion-weighted imagingwhite matter hyperintensityacross the lifespan |
| spellingShingle | Patrick J. Lao Robert S. Vorburger Robert S. Vorburger Atul Narkhede Yunglin Gazes Kay C. Igwe Juliet Colón Erica Amarante Vanessa A. Guzman Briana S. Last Christian Habeck Christian Habeck Yaakov Stern Yaakov Stern Adam M. Brickman Adam M. Brickman White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults Frontiers in Aging Neuroscience white matter microstructure white matter macrostructure diffusion-weighted imaging white matter hyperintensity across the lifespan |
| title | White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults |
| title_full | White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults |
| title_fullStr | White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults |
| title_full_unstemmed | White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults |
| title_short | White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults |
| title_sort | white matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults |
| topic | white matter microstructure white matter macrostructure diffusion-weighted imaging white matter hyperintensity across the lifespan |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00345/full |
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