TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial
β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Sch...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002682 |
| _version_ | 1827871731390349312 |
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| author | Hui-Yeon Jang Su-Jin Jung Eun-Ock Park Soo-Dong Kim Je-Kyoung Kim Soo-Wan Chae Youn–Soo Cha Seung-Ok Lee |
| author_facet | Hui-Yeon Jang Su-Jin Jung Eun-Ock Park Soo-Dong Kim Je-Kyoung Kim Soo-Wan Chae Youn–Soo Cha Seung-Ok Lee |
| author_sort | Hui-Yeon Jang |
| collection | DOAJ |
| description | β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation. |
| first_indexed | 2024-03-12T16:15:03Z |
| format | Article |
| id | doaj.art-01b934db8b99431cb6a2d4c73eac48b0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:03Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-01b934db8b99431cb6a2d4c73eac48b02023-08-09T04:32:31ZengElsevierJournal of Functional Foods1756-46462023-08-01107105668TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trialHui-Yeon Jang0Su-Jin Jung1Eun-Ock Park2Soo-Dong Kim3Je-Kyoung Kim4Soo-Wan Chae5Youn–Soo Cha6Seung-Ok Lee7Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonbuk 54907, Republic of KoreaClinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonbuk 54907, Republic of Korea; Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk 54907, Republic of KoreaClinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonbuk 54907, Republic of KoreaQuegen Biotech. Co., Ltd, Siheung, 15112, Republic of KoreaQuegen Biotech. Co., Ltd, Siheung, 15112, Republic of KoreaClinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonbuk 54907, Republic of Korea; Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk 54907, Republic of KoreaDepartment of Food Science and Human Nutrition & K-Food Research Center, Jeonbuk National University, Jeonbuk 54896, Republic of Korea; Corresponding authors at: Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju, Republic of Korea.Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonbuk 54907, Republic of Korea; Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk 54907, Republic of Korea; Department of Gastroenterology and Hepatology, Jeonbuk National University, Medical School, Jeonbuk 54896, Republic of Korea; Corresponding authors at: Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, Jeonju, Republic of Korea.β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation.http://www.sciencedirect.com/science/article/pii/S1756464623002682Schizophyllum communeβ-glucanGut bacteriaIntestinal healthConstipation |
| spellingShingle | Hui-Yeon Jang Su-Jin Jung Eun-Ock Park Soo-Dong Kim Je-Kyoung Kim Soo-Wan Chae Youn–Soo Cha Seung-Ok Lee TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial Journal of Functional Foods Schizophyllum commune β-glucan Gut bacteria Intestinal health Constipation |
| title | TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial |
| title_full | TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial |
| title_fullStr | TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial |
| title_full_unstemmed | TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial |
| title_short | TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial |
| title_sort | tbg 136 a schizophyllum commune derived β glucan benefits gut microbiota and intestinal health a randomized double blind and placebo controlled clinical trial |
| topic | Schizophyllum commune β-glucan Gut bacteria Intestinal health Constipation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002682 |
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