Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metast...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-08-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221117386 |
| _version_ | 1811216338298863616 |
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| author | Zihe Dong BS Zhipeng Liao BS Yonglin He BS Chengye Wu BS Zixiang Meng BS Baolong Qin BS Ge Xu BS Zeyang Li BS Tianxin Sun BS Yuyan Wen BS Guangjie Li PhD |
| author_facet | Zihe Dong BS Zhipeng Liao BS Yonglin He BS Chengye Wu BS Zixiang Meng BS Baolong Qin BS Ge Xu BS Zeyang Li BS Tianxin Sun BS Yuyan Wen BS Guangjie Li PhD |
| author_sort | Zihe Dong BS |
| collection | DOAJ |
| description | Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis. |
| first_indexed | 2024-04-12T06:36:30Z |
| format | Article |
| id | doaj.art-01baa830ef264484be3a1fe34c697e4d |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-12T06:36:30Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-01baa830ef264484be3a1fe34c697e4d2022-12-22T03:43:50ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-08-012110.1177/15330338221117386Advances in the Biological Functions and Mechanisms of miRNAs in the Development of OsteosarcomaZihe Dong BS0Zhipeng Liao BS1Yonglin He BS2Chengye Wu BS3Zixiang Meng BS4Baolong Qin BS5Ge Xu BS6Zeyang Li BS7Tianxin Sun BS8Yuyan Wen BS9Guangjie Li PhD10 The First School of Clinical Medicine, , Lanzhou, Gansu, China The Second School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First School of Clinical Medicine, , Lanzhou, Gansu, China The First Hospital of Lanzhou University, Lanzhou, Gansu, ChinaOsteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.https://doi.org/10.1177/15330338221117386 |
| spellingShingle | Zihe Dong BS Zhipeng Liao BS Yonglin He BS Chengye Wu BS Zixiang Meng BS Baolong Qin BS Ge Xu BS Zeyang Li BS Tianxin Sun BS Yuyan Wen BS Guangjie Li PhD Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma Technology in Cancer Research & Treatment |
| title | Advances in the Biological Functions and Mechanisms of miRNAs in the Development
of Osteosarcoma |
| title_full | Advances in the Biological Functions and Mechanisms of miRNAs in the Development
of Osteosarcoma |
| title_fullStr | Advances in the Biological Functions and Mechanisms of miRNAs in the Development
of Osteosarcoma |
| title_full_unstemmed | Advances in the Biological Functions and Mechanisms of miRNAs in the Development
of Osteosarcoma |
| title_short | Advances in the Biological Functions and Mechanisms of miRNAs in the Development
of Osteosarcoma |
| title_sort | advances in the biological functions and mechanisms of mirnas in the development of osteosarcoma |
| url | https://doi.org/10.1177/15330338221117386 |
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