Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-022-00956-1 |
| _version_ | 1828300409016418304 |
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| author | Ping Su Dongxu Zhai Albert H. C. Wong Fang Liu |
| author_facet | Ping Su Dongxu Zhai Albert H. C. Wong Fang Liu |
| author_sort | Ping Su |
| collection | DOAJ |
| description | Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19. |
| first_indexed | 2024-04-13T13:09:12Z |
| format | Article |
| id | doaj.art-01bd85fe54a7474ea276fd24032d0e78 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-04-13T13:09:12Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-01bd85fe54a7474ea276fd24032d0e782022-12-22T02:45:40ZengBMCMolecular Brain1756-66062022-08-0115111310.1186/s13041-022-00956-1Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing micePing Su0Dongxu Zhai1Albert H. C. Wong2Fang Liu3Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthCampbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthAbstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19.https://doi.org/10.1186/s13041-022-00956-1Angiotensin-converting enzyme 2 (ACE2)COVID-19Interfering peptideSARS-CoV-2Viral entry |
| spellingShingle | Ping Su Dongxu Zhai Albert H. C. Wong Fang Liu Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Molecular Brain Angiotensin-converting enzyme 2 (ACE2) COVID-19 Interfering peptide SARS-CoV-2 Viral entry |
| title | Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice |
| title_full | Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice |
| title_fullStr | Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice |
| title_full_unstemmed | Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice |
| title_short | Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice |
| title_sort | development of a novel peptide to prevent entry of sars cov 2 into lung and olfactory bulb cells of hace2 expressing mice |
| topic | Angiotensin-converting enzyme 2 (ACE2) COVID-19 Interfering peptide SARS-CoV-2 Viral entry |
| url | https://doi.org/10.1186/s13041-022-00956-1 |
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