Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases
Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/15/4621 |
| _version_ | 1797525223635943424 |
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| author | Lucileno Rodrigues Trindade Davi Vieira Teixeira da Silva Diego dos Santos Baião Vania Margaret Flosi Paschoalin |
| author_facet | Lucileno Rodrigues Trindade Davi Vieira Teixeira da Silva Diego dos Santos Baião Vania Margaret Flosi Paschoalin |
| author_sort | Lucileno Rodrigues Trindade |
| collection | DOAJ |
| description | Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance. |
| first_indexed | 2024-03-10T09:10:43Z |
| format | Article |
| id | doaj.art-01c0ed317deb4409bfa5bf18fa595188 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:10:43Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-01c0ed317deb4409bfa5bf18fa5951882023-11-22T06:00:49ZengMDPI AGMolecules1420-30492021-07-012615462110.3390/molecules26154621Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular DiseasesLucileno Rodrigues Trindade0Davi Vieira Teixeira da Silva1Diego dos Santos Baião2Vania Margaret Flosi Paschoalin3Chemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitária, Rio de Janeiro 21941-909, BrazilChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitária, Rio de Janeiro 21941-909, BrazilChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitária, Rio de Janeiro 21941-909, BrazilChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitária, Rio de Janeiro 21941-909, BrazilPolyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance.https://www.mdpi.com/1420-3049/26/15/4621nanocarriersantioxidantsbioavailabilitycardiovascular healthpolyphenol-loaded nanoparticlespre-clinical trials |
| spellingShingle | Lucileno Rodrigues Trindade Davi Vieira Teixeira da Silva Diego dos Santos Baião Vania Margaret Flosi Paschoalin Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases Molecules nanocarriers antioxidants bioavailability cardiovascular health polyphenol-loaded nanoparticles pre-clinical trials |
| title | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases |
| title_full | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases |
| title_fullStr | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases |
| title_full_unstemmed | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases |
| title_short | Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases |
| title_sort | increasing the power of polyphenols through nanoencapsulation for adjuvant therapy against cardiovascular diseases |
| topic | nanocarriers antioxidants bioavailability cardiovascular health polyphenol-loaded nanoparticles pre-clinical trials |
| url | https://www.mdpi.com/1420-3049/26/15/4621 |
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