CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth. Using a combination of immune-deficient and immune-competent mouse models, we now establish that loss...

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Bibliographic Details
Main Authors: Abdul S. Qadir, Jean Philippe Guégan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoué, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Immunology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221013171

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221013171

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