Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review
The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.654087/full |
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| author | Xianggang Wang Xianggang Wang Zuhao Li Zuhao Li Chenyu Wang Haotian Bai Haotian Bai Zhonghan Wang Zhonghan Wang Yuzhe Liu Yuzhe Liu Yirui Bao Ming Ren Ming Ren He Liu He Liu Jincheng Wang Jincheng Wang |
| author_facet | Xianggang Wang Xianggang Wang Zuhao Li Zuhao Li Chenyu Wang Haotian Bai Haotian Bai Zhonghan Wang Zhonghan Wang Yuzhe Liu Yuzhe Liu Yirui Bao Ming Ren Ming Ren He Liu He Liu Jincheng Wang Jincheng Wang |
| author_sort | Xianggang Wang |
| collection | DOAJ |
| description | The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries. |
| first_indexed | 2024-12-17T01:57:10Z |
| format | Article |
| id | doaj.art-01c21db3f80e443da7b471ac3ad6f283 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-17T01:57:10Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-01c21db3f80e443da7b471ac3ad6f2832022-12-21T22:07:55ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-06-01910.3389/fbioe.2021.654087654087Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A ReviewXianggang Wang0Xianggang Wang1Zuhao Li2Zuhao Li3Chenyu Wang4Haotian Bai5Haotian Bai6Zhonghan Wang7Zhonghan Wang8Yuzhe Liu9Yuzhe Liu10Yirui Bao11Ming Ren12Ming Ren13He Liu14He Liu15Jincheng Wang16Jincheng Wang17Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaDepartment of Orthopedics, Chinese PLA 965 Hospital, Jilin, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, ChinaOrthopaedic Research Institute of Jilin Province, Changchun, ChinaThe growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.https://www.frontiersin.org/articles/10.3389/fbioe.2021.654087/fullgrowth platecartilage tissue engineeringscaffoldbone marrow mesenchymal stem cellsthree-dimensional printing |
| spellingShingle | Xianggang Wang Xianggang Wang Zuhao Li Zuhao Li Chenyu Wang Haotian Bai Haotian Bai Zhonghan Wang Zhonghan Wang Yuzhe Liu Yuzhe Liu Yirui Bao Ming Ren Ming Ren He Liu He Liu Jincheng Wang Jincheng Wang Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review Frontiers in Bioengineering and Biotechnology growth plate cartilage tissue engineering scaffold bone marrow mesenchymal stem cells three-dimensional printing |
| title | Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review |
| title_full | Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review |
| title_fullStr | Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review |
| title_full_unstemmed | Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review |
| title_short | Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review |
| title_sort | enlightenment of growth plate regeneration based on cartilage repair theory a review |
| topic | growth plate cartilage tissue engineering scaffold bone marrow mesenchymal stem cells three-dimensional printing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.654087/full |
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