The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases
The accurate regulation of the microenvironment within the nervous system is one of the key features characterizing complex organisms. To this end, neural tissue has to be physically separated from circulation, but at the same time, mechanisms must be in place to allow controlled transport of nutrie...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996123000852 |
| _version_ | 1797847266597273600 |
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| author | Esteban G. Contreras Christian Klämbt |
| author_facet | Esteban G. Contreras Christian Klämbt |
| author_sort | Esteban G. Contreras |
| collection | DOAJ |
| description | The accurate regulation of the microenvironment within the nervous system is one of the key features characterizing complex organisms. To this end, neural tissue has to be physically separated from circulation, but at the same time, mechanisms must be in place to allow controlled transport of nutrients and macromolecules into and out of the brain. These roles are executed by cells of the blood-brain barrier (BBB) found at the interface of circulation and neural tissue. BBB dysfunction is observed in several neurological diseases in human. Although this can be considered as a consequence of diseases, strong evidence supports the notion that BBB dysfunction can promote the progression of brain disorders. In this review, we compile the recent evidence describing the contribution of the Drosophila BBB to the further understanding of brain disease features in human patients. We discuss the function of the Drosophila BBB during infection and inflammation, drug clearance and addictions, sleep, chronic neurodegenerative disorders and epilepsy. In summary, this evidence suggests that the fruit fly, Drosophila melanogaster, can be successfully employed as a model to disentangle mechanisms underlying human diseases. |
| first_indexed | 2024-04-09T18:08:33Z |
| format | Article |
| id | doaj.art-01c221873bc642af931845ae83d15b86 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-09T18:08:33Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-01c221873bc642af931845ae83d15b862023-04-14T04:18:43ZengElsevierNeurobiology of Disease1095-953X2023-05-01180106071The Drosophila blood-brain barrier emerges as a model for understanding human brain diseasesEsteban G. Contreras0Christian Klämbt1Corresponding authors.; University of Münster, Institute of Neuro- and Behavioral Biology, Badestr. 9, Münster, GermanyCorresponding authors.; University of Münster, Institute of Neuro- and Behavioral Biology, Badestr. 9, Münster, GermanyThe accurate regulation of the microenvironment within the nervous system is one of the key features characterizing complex organisms. To this end, neural tissue has to be physically separated from circulation, but at the same time, mechanisms must be in place to allow controlled transport of nutrients and macromolecules into and out of the brain. These roles are executed by cells of the blood-brain barrier (BBB) found at the interface of circulation and neural tissue. BBB dysfunction is observed in several neurological diseases in human. Although this can be considered as a consequence of diseases, strong evidence supports the notion that BBB dysfunction can promote the progression of brain disorders. In this review, we compile the recent evidence describing the contribution of the Drosophila BBB to the further understanding of brain disease features in human patients. We discuss the function of the Drosophila BBB during infection and inflammation, drug clearance and addictions, sleep, chronic neurodegenerative disorders and epilepsy. In summary, this evidence suggests that the fruit fly, Drosophila melanogaster, can be successfully employed as a model to disentangle mechanisms underlying human diseases.http://www.sciencedirect.com/science/article/pii/S0969996123000852Drosophila melanogasterBlood-brain barrierNeurological diseasesGlial cells |
| spellingShingle | Esteban G. Contreras Christian Klämbt The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases Neurobiology of Disease Drosophila melanogaster Blood-brain barrier Neurological diseases Glial cells |
| title | The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases |
| title_full | The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases |
| title_fullStr | The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases |
| title_full_unstemmed | The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases |
| title_short | The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases |
| title_sort | drosophila blood brain barrier emerges as a model for understanding human brain diseases |
| topic | Drosophila melanogaster Blood-brain barrier Neurological diseases Glial cells |
| url | http://www.sciencedirect.com/science/article/pii/S0969996123000852 |
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