Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.
Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4807009?pdf=render |
| _version_ | 1818328021338161152 |
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| author | Lisha Tang Hengrui Zhu Xianmei Yang Fang Xie Jingtao Peng Deke Jiang Jun Xie Meiyan Qi Long Yu |
| author_facet | Lisha Tang Hengrui Zhu Xianmei Yang Fang Xie Jingtao Peng Deke Jiang Jun Xie Meiyan Qi Long Yu |
| author_sort | Lisha Tang |
| collection | DOAJ |
| description | Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of β-catenin. Collectively, this study demonstrated that shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway. |
| first_indexed | 2024-12-13T12:25:32Z |
| format | Article |
| id | doaj.art-01c28ae8bbae48be90903ef263e632b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T12:25:32Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-01c28ae8bbae48be90903ef263e632b12022-12-21T23:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015201210.1371/journal.pone.0152012Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway.Lisha TangHengrui ZhuXianmei YangFang XieJingtao PengDeke JiangJun XieMeiyan QiLong YuNatural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of β-catenin. Collectively, this study demonstrated that shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway.http://europepmc.org/articles/PMC4807009?pdf=render |
| spellingShingle | Lisha Tang Hengrui Zhu Xianmei Yang Fang Xie Jingtao Peng Deke Jiang Jun Xie Meiyan Qi Long Yu Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. PLoS ONE |
| title | Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. |
| title_full | Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. |
| title_fullStr | Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. |
| title_full_unstemmed | Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. |
| title_short | Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway. |
| title_sort | shizukaol d a dimeric sesquiterpene isolated from chloranthus serratus represses the growth of human liver cancer cells by modulating wnt signalling pathway |
| url | http://europepmc.org/articles/PMC4807009?pdf=render |
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