The regulatory mechanism and potential application of IL-23 in autoimmune diseases

The regulatory mechanism and potential application of IL-23 in autoimmune diseases

IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family. It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune responses, stimulating the differentiation and prolife...

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Bibliographic Details
Main Authors: De-Kai Xiong, Xiang Shi, Miao-Miao Han, Xing-Min Zhang, Na-Na Wu, Xiu-Yue Sheng, Ji-Nian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
IL-23
IL-23R
IL-23/TH17 axis
autoimmune diseases
RA
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.982238/full

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